IPTG, Dioxane-Free An analogue of allolactose that binds specifically to the repressor protein of the lac operon

IPTG, Dioxane-Free (CAS 367-93-1)

IPTG, Dioxane-Free | CAS 367-93-1 is rated 5.0 out of 5 by 1.
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Synonym: Isopropyl-β-D-thiogalactoside
Application: An analogue of allolactose that binds specifically to the repressor protein of the lac operon
CAS Number: 367-93-1
Purity: ≥98%
Molecular Weight: 238.30
Molecular Formula: C9H18O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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IPTG, Dioxane-Free (isopropyl-β-thiogalactoside) is an analogue of allolactose that binds specifically to the repressor protein of the lac operon and induces expression of β-galactosidase in Escherichia coli. The compound is widely used with X-Gal (sc-280488) plates to screen for blue and white colonies. The lac operon system and IPTG have been used in multiple cloning experiments and cellular systems to study gene activity.


References

1. Cho, S., et al. 1985. Biochem. Biophys. Res. Commun. 128: 1268-1273. PMID: 3924043
2. Date, T., et al. 1988. Biochemistry. 27: 2983-2990. PMID: 3042024
3. Rodriguez, J.F. and Smith, G.L. 1990. Nucleic Acids Res. 18: 5347-5351. PMID: 2216706
4. Zhang, Y.F., et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 1511-1515. PMID: 1899929
5. Morita, Y., et al. 2010. J. Microbiol. Methods. 82: 205-213. PMID: 20538017
6. Phan, T.T., et al. 2010. Protein Expr. Purif. 71: 174-178. PMID: 19963063

Usage :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in water, and methanol.
Storage :
Store at 4° C
Melting Point :
110-114° C
Boiling Point :
438.42° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D -31.5°±3.0°, c = 1 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
656894
Merck Index :
14: 5082
MDL Number :
MFCD00063273
EC Number :
206-703-0
Beilstein Registry :
4631
SMILES :
CC(C)S[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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IPTG, Dioxane-Free  Product Citations

See how others have used IPTG, Dioxane-Free. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 27476989  Dudley, QM. et al. 2016. ACS Synth Biol. 5: 1578-1588.

PMID: # 25993260  Possik, E. et al. 2015. Journal of visualized experiments : JoVE. e52746.

PMID: # 12183631  Elowitz, MB. et al. 2002. Science. 297: 1183-1186.

PMID: # 9608745  Hansen, LH. et al. 1998. Curr. Microbiol. 36: 341-347.

PMID: # 7540285  Chao, MY. et al. 1995. Nucleic Acids Res. 23: 1691-1695.

PMID: # 7639751  Hayashi, Y. et al. 1995. Biochem. Biophys. Res. Commun. 213: 317-324.

PMID: # 8074516  Boyd, A. et al. 1994. Appl. Environ. Microbiol. 60: 2355-2359.

PMID: # 1899929  Zhang, YF. et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 1511-1515.

PMID: # 2216706  Rodriguez, JF. et al. 1990. Nucleic Acids Res. 18: 5347-5351.

PMID: # 2542231  Eckert, B. et al. 1989. J. Bacteriol. 171: 3557-3559.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Works well in cell culture Works well in cell culture.
Date published: 2015-03-24
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