Ipsapirone

Ipsapirone (CAS 95847-70-4)

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Application: A selective SR-1A agonist
CAS Number: 95847-70-4
Purity: ≥99%
Molecular Weight: 401.48
Molecular Formula: C19H23N5O3S
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Ipsapirone, also known as TVX Q 7821, is a SR-1A agonist and has been found to selectively bind to SR-1 receptors. Only at high doses, this compound shows the ability to inhibit 1-adrenergic and SR-2 function. Exposure of ethanol treated rhombencephalic neurons to Ipsapirone has been reported to prevent ethanol-associated apoptosis of the cells and also activate the PI3K/Akt pro-survival pathway. Additionally, the expression of NF-κB dependent anti-apoptotic genes as well as Bcl-XL, catalase, and XIAP expression were augmented in the rhombencephalic neurons.


References

1. Traber, J., et al. 1984. Brain Res. Bull. 12: 741-744. PMID: 6541079
2. Glaser, T. and Traber, J. 1985. Naunyn Schmiedebergs Arch. Pharmacol. 329: 211-215. PMID: 3160954
3. Maj, J., et al. 1987. J. Neural Transm. 70: 1-17. PMID: 2889795
4. Lee, J.H., et al. 2009. Brain Res. 1249: 54-60. PMID: 18992726

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM).
Storage :
Store at room temperature
Melting Point :
249.79° C (Predicted)
Boiling Point :
629.83° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Serotonin 1a receptor: IC50 = 8.2 nM (rat); Adrenergic receptor alpha-1: IC50 = 0.5 µM (human); Adrenergic receptor alpha-2: IC50 = 1 µM (human); D3DR: IC50 = 1.2 µM (human); D4DR: IC50 = 1.8 µM (human)
Ki Data :
Serotonin 1a receptor: Ki= 3.4 nM (rat); 5-HT1A receptor : Ki= 10 nM; α1D-AR: Ki= 46 nM (human); α1A-AR: Ki= 87 nM (human); D2DR: Ki= 110 nM (human)
pK Values :
pKb: 7.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DE4840000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
56971
MDL Number :
MFCD00866976
Beilstein Registry :
5486134
SMILES :
C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4

Download SDS (MSDS)

Certificate of Analysis

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