Ionomycin free acid A potent and selective calcium ionophore

Ionomycin free acid (CAS 56092-81-0)

Ionomycin free acid | CAS 56092-81-0 is rated 5.0 out of 5 by 1.
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Synonym: SQ 23377
Application: A potent and selective calcium ionophore
CAS Number: 56092-81-0
Molecular Weight: 709.01
Molecular Formula: C41H72O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ionomycin free acid is an antibiotic selective calcium ionophore, which can extract calcium ions from aqueous phase to organic phase. In addition, Ionomycin free acid acts as a transport carrier, which helps transport cations across solvent barriers. Studies indicate that this antibiotic can transport other ions such as Mg, Sr, and Ba with a weaker affinity. It is known that Ionomycin free acid is produced by Streptomyces conglobatus. Furthermore, Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane.


References

1. Liu, C. and Hermann, T.E. 1978. J. Biol. Chem. 253: 5892-5894. PMID: 28319
2. Kauffman, R.F., et al. 1980. J. Biol. Chem. 255: 2735-2739. PMID: 6766939
3. Elzi, D.J., et al. 2001. Am. J. Physiol., Cell Physiol. 281: C350-C360. PMID: 11401859

Physical State :
Solid
Solubility :
Solubility: Soluble to 10 mM in Ethanol and to 10 mM in DMSO.
Storage :
Store at -20° C
Boiling Point :
817.21° C at 760 mmHg (Predicted)
Density :
1.07 g/mL (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3733
MDL Number :
MFCD06798385
SMILES :
CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O

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Certificate of Analysis

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Ionomycin free acid  Product Citations

See how others have used Ionomycin free acid. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27392939  Chakraborty, S. et al. 2016. Apoptosis. 21: 1106-24.

PMID: # 27210812  Cui, R. et al. 2016. Antiviral Res. 132: 38-45.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Elzi et al Elzi et al. (PubMed ID 11401859) found that the ionophore, ionomycin, activated the p38 and p42/44 mitogen-activated kinases in human neutrophils. -SCBT Publication Review
Date published: 2015-01-19
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