Ionomycin A polyether antibiotic and apoptotic degeneration inducer

Ionomycin (CAS 56092-82-1)

Ionomycin | CAS 56092-82-1 is rated 5.0 out of 5 by 3.
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Synonym: Ionomycin Calcium Salt
Application: A polyether antibiotic and apoptotic degeneration inducer
CAS Number: 56092-82-1
Purity: ≥98%
Molecular Weight: 747.07
Molecular Formula: C41H70O9•Ca
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ionomycin (Ca) from Streptomyces conglobatus is a nonfluorescent ionophoric antibiotic employed in research focused on Ca2+ transport across biological membranes; it is a highly selective and potent calcium ionophore. The Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.


References

1. Kuznetsov, G., et al. 1992. J. Biol. Chem. 267: 3932-3939. PMID: 1740441
2. Lee, H.C., 1993. J. Biol. Chem. 268: 293-299. PMID: 8416936
3. Dupuy d'Angeac, A., et al. 1993. J. Cell. Physiol. 154: 44-52. PMID: 8419406
4. Takei, N. and Endo, Y. 1994. Brain Res. 652: 65-70. PMID: 7525020
5. Sreedhar, A.S., et al. 2002. J. Cell. Biochem. 86: 154-161. PMID: 12112026
6. Park, C.H., et al. 2005. Carcinogenesis. 26: 1929-1933. PMID: 15930030

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (7 mg/ml), methanol (5 mg/ml), and DMSO (10 mg/ml). Insoluble in water.
Storage :
Desiccate at 4° C
Melting Point :
205° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NO0650000
PubChem CID :
6446270
MDL Number :
MFCD00151183
SMILES :
C[C@H](CCC(=O)[O-])C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\[O-].[Ca+2]

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Ionomycin  Product Citations

See how others have used Ionomycin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 37 total

PMID: # 28521134  Tortosa, E. et al. 2017. Neuron. 94: 809-825.e7.

PMID: # 28202940  Ovciarikova, J. et al. 2017. Sci Rep. 7: 42746.

PMID: # 26884717  Yu, W. et al. 2016. Int. J. Biol. Sci. 12: 198-209.

PMID: # 26832790  van der Watt, PJ. et al. 2016. Mol. Cancer Ther.

PMID: # 25545753  Zimmermann, J. et al. 2015. Eur. J. Immunol. 45: 1270-3.

PMID: # 25996296  Montagne, R. et al. 2015. Cell Death Dis. 6: e1769.

PMID: # 25947381  Lhuillier, C. et al. 2015. J. Biol. Chem. 290: 16797-811.

PMID: # 26046259  Sheehy, RM. et al. 2015. Cancer Biol. Ther. 16: 1259-68.

PMID: # 25198179  Tsai, PJ. et al. 2015. Cell Transplant. 24: 1555-70.

PMID: # 25087184  Limm, K. et al. 2014. Eur. J. Cancer. 50: 2714-24.

Citations 1 to 10 of 37 total

What is the Country of Origin?

Asked by: SCM4
This product originates in Israel.
Answered by: Tech Service 11
Date published: 2017-03-17

What is the expected color of this product?

Asked by: chemicalsmg
Thank you for your question. Ionomycin: sc-3592 is expected to be white to off-white in color.
Answered by: Chemical Support 3
Date published: 2017-03-10
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Rated 5 out of 5 by from Use this routinely in the lab and works well Use this routinely in the lab and works well.
Date published: 2015-08-12
Rated 5 out of 5 by from No comment No comment.
Date published: 2015-04-06
Rated 5 out of 5 by from Commonly used in research that is focused Commonly used in research that is focused on calcium transport across membranes. Used to stimulate whole human blood, then cells were stained with antibodies against CD69 and IFN- to show its affect. A decrease in the levels of IFN- was seen, and an increase in expression of CD69 (looks to be a small increase) by flow cytometry. -SCBT QC
Date published: 2015-02-13
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