Ionomycin Ionomycin (Ca) is a highly selective and potent calcium ionophore which serves as a useful tool for increasing intracellular Ca2+ concentrations. A non-fluorescent antibiotic and more effective than A23187 (sc-3591).

Ionomycin  (CAS 56092-82-1)

Ionomycin is rated 5.0 out of 5 by 3.
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| See 34 Citations
Synonym: Ionomycin Calcium Salt
Application: A polyether antibiotic and apoptotic degeneration inducer
CAS Number: 56092-82-1
Purity: ≥98%
Molecular Weight: 747.07
Molecular Formula: C41H70O9•Ca
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Ionomycin sc-3592 1 mg $69.00
Ionomycin sc-3592A 5 mg $259.00

Ionomycin (Ca) from Streptomyces conglobatus is a nonfluorescent ionophoric antibiotic employed in research focused on Ca2+ transport across biological membranes; it is a highly selective and potent calcium ionophore. The Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.


References

1. Kuznetsov, G., et al. 1992. J. Biol. Chem. 267: 3932-3939. PMID: 1740441
2. Lee, H.C., 1993. J. Biol. Chem. 268: 293-299. PMID: 8416936
3. Dupuy d'Angeac, A., et al. 1993. J. Cell. Physiol. 154: 44-52. PMID: 8419406
4. Takei, N. and Endo, Y. 1994. Brain Res. 652: 65-70. PMID: 7525020
5. Sreedhar, A.S., et al. 2002. J. Cell. Biochem. 86: 154-161. PMID: 12112026
6. Park, C.H., et al. 2005. Carcinogenesis. 26: 1929-1933. PMID: 15930030

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (7 mg/ml), methanol (5 mg/ml), and DMSO (10 mg/ml). Insoluble in water.
Storage :
Desiccate at 4° C
Melting Point :
204-206
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NO0650000
PubChem CID :
6446270
MDL Number :
MFCD00151183
SMILES :
C[C@H](CCC(=O)[O-])C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)[O-].[Ca+2]

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Certificate of Analysis

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Ionomycin Product Citations

See how others have used Ionomycin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 34 total

PMID: # 26884717
Yu, W. et al. 2016. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int. J. Biol. Sci.. 12: 198-209.

PMID: # 26832790
van der Watt, PJ. et al. 2016. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol. Cancer Ther..

PMID: # 25545753
Zimmermann, J. et al. 2015. A Ca(2+) concentration of 1.5 mM, as present in IMDM but not in RPMI, is critical for maximal response of Th cells to PMA/ionomycin. Eur. J. Immunol.. 45: 1270-3.

PMID: # 25947381
Lhuillier, C. et al. 2015. Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION. J. Biol. Chem.. 290: 16797-811.

PMID: # 26046259
Sheehy, RM. et al. 2015. Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biol. Ther.. 16: 1259-68.

PMID: # 25198179
Tsai, PJ. et al. 2015. Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice. Cell Transplant. 24: 1555-70.

PMID: # 25087184
Limm, K. et al. 2014. The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma. Eur. J. Cancer. 50: 2714-24.

PMID: # 24127617
Model, MA. et al. 2013. Optical determination of intracellular water in apoptotic cells. J. Physiol. (Lond.). 591: 5843-9.

PMID: # 24091941
Xiong, Y. et al. 2013. Human TTC5, a novel tetratricopeptide repeat domain containing gene, activates p53 and inhibits AP-1 pathway. Mol. Biol. Rep.. 40: 6183-8.

PMID: # 23959938
Holmes, S. et al. 2013. Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells. Endocrinology. 154: 4281-92.

Citations 1 to 10 of 34 total
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Rated 5 out of 5 by from Use this routinely in the lab and works well Use this routinely in the lab and works well.
Date published: 2015-08-12
Rated 5 out of 5 by from No comment No comment.
Date published: 2015-04-06
Rated 5 out of 5 by from Commonly used in research that is focused Commonly used in research that is focused on calcium transport across membranes. Used to stimulate whole human blood, then cells were stained with antibodies against CD69 and IFN- to show its affect. A decrease in the levels of IFN- was seen, and an increase in expression of CD69 (looks to be a small increase) by flow cytometry. -SCBT QC
Date published: 2015-02-13
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