INDYA stem cell reagent that reverses aberrant tau-phosphorylation

INDY (CAS 1169755-45-6)

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Synonym: (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Application: A stem cell reagent that reverses aberrant tau-phosphorylation
CAS Number: 1169755-45-6
Molecular Weight: 235.30
Molecular Formula: C12H13NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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INDY is a stem cell reagent that reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. INDY impairs the self-renewal capacity of subventricular zone neural stem cells. INDY is also a Dyrk1A/B inhibitor, IC50 values are 0.23 and 0.24 μM, for Dyrk1B and Dyrk1A, respectively.


References

1. Ogawa, Yasushi., et al., 2010. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature communications. 1(): 86. PMID: 20981014
2. Pozo, Natividad., et al., 2013. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. The Journal of clinical investigation. 123(6): 2475-87. PMID: 23635774

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
146.98 °C (Predicted)
Boiling Point :
~409.2 °C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
IC50 :
Dyrk1B: IC50 = 0.23 µM; Dyrk1A: IC50 = 0.24 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
69538603
SMILES :
CCN1C2=C(C=CC(=C2)O)SC1=CC(=O)C

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Certificate of Analysis

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