INDY is a stem cell reagent that reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. INDY impairs the self-renewal capacity of subventricular zone neural stem cells. INDY is also a Dyrk1A/B inhibitor, IC50 values are 0.23 and 0.24 μM, for Dyrk1B and Dyrk1A, respectively.
1. Ogawa, Yasushi., et al., 2010. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature communications. 1(): 86. PMID: 20981014
2. Pozo, Natividad., et al., 2013. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. The Journal of clinical investigation. 123(6): 2475-87. PMID: 23635774
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