Indolmycin An antibiotic that inhibits bacterial tryptophanyl-tRNA synthetase

Indolmycin (CAS 21200-24-8)

Indolmycin | CAS 21200-24-8 is rated 5.0 out of 5 by 1.
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Synonym: Antibiotic PA 155A
Application: An antibiotic that inhibits bacterial tryptophanyl-tRNA synthetase
CAS Number: 21200-24-8
Purity: >99%
Molecular Weight: 257.29
Molecular Formula: C14H15N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Indolmycin is a naturally occurring antibiotic that acts against Staphylococci and Helicobacter pylori. The compound is a secondary metabolite of Streptomyces griseus with the ability to inhibit bacterial tryptophanyl-tRNA synthetase.


References

1. Werner, R.G., et al. 1976. Eur. J. Biochem. 68: 1-3. PMID: 786633
2. Bogosian, G., et al. 1983. J. Bacteriol. 153: 1120-1123. PMID: 6337120
3. Hasuoka, A., et al. 2001. Chem. Pharm. Bull. 49: 1604-1608. PMID: 11767081
4. Kitabatake, M., et al. 2002. J. Biol. Chem. 277: 23882-23887. PMID: 11970956
5. Hurdle, J.G., et al. 2004. J. Antimicrob. Chemother. 54: 549-552. PMID: 15243028
6. Vecchione, J.J., et al. 2009. Antimicrob. Agents Chemother. 53: 3972-3980. PMID: 19546369

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp. MST-AS5532
Solubility :
Soluble in ethanol, methanol, DMSO, DMF, and water (poor).
Storage :
Store at -20° C
Melting Point :
186.82° C (Predicted)
Boiling Point :
420.75° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKa: 0.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3082186
MDL Number :
MFCD01747966
SMILES :
CC(C1C(=O)N=C(O1)NC)C2=CNC3=CC=CC=C32

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Hurdle et al Hurdle et al. (PubMed ID 15243028) found that Indolmycin showed bacteriostatic activity against staphylococcal infections like MSSA (methicillin-susceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycin-intermediate S. aureus). -SCBT Publication Review
Date published: 2015-07-07
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