Indolmycin is a naturally occurring antibiotic that acts against Staphylococci and Helicobacter pylori. The compound is a secondary metabolite of Streptomyces griseus with the ability to inhibit bacterial tryptophanyl-tRNA synthetase.
1. Werner, R.G., et al. 1976. Eur. J. Biochem. 68: 1-3. PMID: 786633 2. Bogosian, G., et al. 1983. J. Bacteriol. 153: 1120-1123. PMID: 6337120 3. Hasuoka, A., et al. 2001. Chem. Pharm. Bull. 49: 1604-1608. PMID: 11767081 4. Kitabatake, M., et al. 2002. J. Biol. Chem. 277: 23882-23887. PMID: 11970956 5. Hurdle, J.G., et al. 2004. J. Antimicrob. Chemother. 54: 549-552. PMID: 15243028 6. Vecchione, J.J., et al. 2009. Antimicrob. Agents Chemother. 53: 3972-3980. PMID: 19546369
Streptomyces sp. MST-AS5532
Soluble in ethanol, methanol, DMSO, DMF, and water (poor).
Store at -20° C
186.82° C (Predicted)
420.75° C at 760 mmHg (Predicted)
1.36 g/cm3 (Predicted)
n20D 1.67 (Predicted)
pKa: 0.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Certificate of Analysis
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Hurdle et alHurdle et al. (PubMed ID 15243028) found that Indolmycin showed bacteriostatic activity against staphylococcal infections like MSSA (methicillin-susceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycin-intermediate S. aureus). -SCBT Publication Review
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