(-)-Indolactam V A protein kinase C activator; also can direct the differentiation of human ESCs

(-)-Indolactam V (CAS 90365-57-4)

(-)-Indolactam V | CAS 90365-57-4 is rated 5.0 out of 5 by 1.
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Synonym: (-)-ILV
Application: A protein kinase C activator; also can direct the differentiation of human ESCs
CAS Number: 90365-57-4
Purity: ≥95%
Molecular Weight: 301.38
Molecular Formula: C17H23N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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(-)-Indolactam V is a potent activator of protein kinase C (PKC). This compound exhibits tumor-promoting activity and directs the differentiation of human embryonic stem cells into pancreatic progenitors.


References

1. Heikkilä, J., et al., 1989. (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells. Biochemical and biophysical research communications. 162(3): 1207-13. PMID: 2764930
2. Fujiki, H., et al., 1984. Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin. Gann = Gan. 75(10): 866-70. PMID: 6595181
3. Shieh, H L., et al., 1995. Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay. Molecular carcinogenesis. 12(3): 166-76. PMID: 7893369
4. Lee, C E., et al., 1993. Interleukin-4 signals regulating CD23 gene expression in human B cells: protein kinase C-independent signaling pathways. Cellular immunology. 146(1): 171-85. PMID: 8425225

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), and ethanol.
Storage :
Store at 4° C
Melting Point :
226.48° C (Predicted)
Boiling Point :
584.01° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
HL-60 (Promyeloblast leukemia cells): EC5050 = 5 nM (human)
Ki Data :
Protein kinase C delta: Ki= 2.01 nM (Mus musculus); Protein kinase C eta: Ki= 5.5 nM (human)
pK Values :
pKb: 0.74
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UY8547000
PubChem CID :
105000
MDL Number :
MFCD00151197
SMILES :
CC(C)C1C(=O)NC(CC2=CNC3=C2C(=CC=C3)N1C)CO

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Certificate of Analysis

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(-)-Indolactam V  Product Citations

See how others have used (-)-Indolactam V. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26431317  Glover, KP. et al. 2015. PLoS ONE. 10: e0139850.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Shieh et al Shieh et al. (PubMed ID 7893369) found that Indolactam V inhibited native bovine PKC alpha activity in a phenotypic yeast assay. -SCBT Publication Review
Date published: 2015-05-05
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