Indirubin-5-sulfonic acid sodium salt A CDK and GSK-3β inhibitor

Indirubin-5-sulfonic acid sodium salt

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Synonym: E226; Indirubin-5-sulphonate sodium salt
Application: A CDK and GSK-3β inhibitor
Purity: ≥95%
Molecular Weight: 364.31
Molecular Formula: C16H9N2O5S•Na
* Refer to Certificate of Analysis for lot specific data (including water content).

Indirubin-5-sulfonic acid sodium salt is a cyclin-dependent kinase (CDK) inhibitor, in particular CDK1/cyclin B (IC50 = 55 nM), CDK2/cyclin A (IC50 = 35 nM), CDK2/cyclin E (IC50 = 150 nM), CDK4/cyclin D1(IC50 = 300 nM), and CDK5/p35 (IC50 = 65 nM), with additional inhibitory activity against GSK-3β.


References

1. Hoessel, R., et al., 1999. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature cell biology. 1(1): 60-7. PMID: 10559866
2. Leclerc, S., et al., 2001. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of biological chemistry. 276(1): 251-60. PMID: 11013232
3. Marko, D., et al., 2001. Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. British journal of cancer. 84(2): 283-9. PMID: 11161389
4. Davies, T G., et al., 2001. Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Structure (London, England : 1993). 9(5): 389-97. PMID: 11377199

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and water.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.73 (Predicted)
IC50 :
CDK2/cyclin A: IC50 = 35 nM; CDK1/cyclin B: IC50 = 55 nM; CDK5/p35: IC50 = 65 nM; CDK2/cyclin E: IC50 = 150 nM; Flt-3/Flk-2: IC50 = 0.28 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1=CC=C2C(=C1)C(=O)/C(=C/3\C4=C(C=CC(=C4)S(=O)(=O)[O-])NC3=O)/N2.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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