Imipenem Monohydrate A third generation cephalosporin and β-lactam antibiotic

Imipenem Monohydrate (CAS 64221-86-9)

Imipenem Monohydrate | CAS 64221-86-9 is rated 4.0 out of 5 by 1.
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Synonym: N-Formimidoylthienamycin
Application: A third generation cephalosporin and β-lactam antibiotic
CAS Number: 64221-86-9
Purity: ≥95%
Molecular Weight: 317.36
Molecular Formula: C12H17N3O4S•H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Imipenem is a third generation cephalosporin antibiotic. Studies report that Pseudomonas aeruginosa exposed to Impenem shows higher resistancy when treated with zinc eluted from siliocinized latex. In addition, Pseudomonas aeruginosa studies show that loss of the DOR-1 (OprD) porin protein leads to Imipenen resistance. Research indicates that the DOR-1 (OprD) porin protein is an outer membrane porin protein located near the proB gene.


References

1. Shibata, K., et al. 1997. J. Antibiot. 50: 135-138. PMID: 9099222
2. Morimoto, Y., et al. 2006. Spec Care Dentist. 26: 209-213. PMID: 17249442
3. Farra, A., et al. 2008. Int. J. Antimicrob. Agents. 31: 427-433. PMID: 18375104
4. Pichardo, C., et al. 2010. Eur. J. Clin. Microbiol. Infect. Dis. [Epub ahead of print]. PMID: 20936490
5. Naenna, P., et al. 2010. Southeast Asian J. Trop. Med. Public Health. 41: 614-624. PMID: 20578550

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (>5 mg/ml).
Storage :
Store at room temperature
Boiling Point :
567.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
Staphylococcus aureus: IC50 = 26.72 nM; Penicillin-binding protein 2x: IC50 = 60.13 nM (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 1A: IC50 = 86.85 nM (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 2B: IC50 = 153.67 nM (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 2: IC50 = 334.06 nM (Streptococcus pneumoniae serotype 4 )
Ki Data :
PER-2 β-lactamase: Ki= 60 nM (Citrobacter freundii)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5282372
Merck Index :
14: 4919
MDL Number :
MFCD09753321
SMILES :
C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O

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Imipenem Monohydrate  Product Citations

See how others have used Imipenem Monohydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24475102  Chung, FH. et al. 2014. PLoS ONE. 9: e86299.

Citations 1 to 1 of 1 total

is it possible to order imipenem in bulkj? can you give me amount ranges and pricing? e.g. 25 mg- 50 mg, 50 mg-150 mg, 150 mg-250 mg . thank you Lorenzo

Asked by: Lorenzo Giacani
Thank you for your question. Please contact our Special Orders Department to inquire about the possibility of a bulk order for this biochemical. Email us at specialorders@scbt.com. Or you can call us directly at (800) 457-3801 option 2.
Answered by: Tech Service
Date published: 2016-10-24
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Rated 4 out of 5 by from Uses for in vivo experiments Uses for in vivo experiments.
Date published: 2015-06-12
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