Imidazole

Imidazole (CAS 288-32-4)

Imidazole | CAS 288-32-4 is rated 5.0 out of 5 by 2.
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Synonym: 1,3-Diaza-2,4-cyclopentadiene
Application: A buffer useful in the pH range of 6.2-7.8
CAS Number: 288-32-4
Purity: ≥99%
Molecular Weight: 68.08
Molecular Formula: C3H4N2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Imidazole is useful as a buffer in the pH range of 6.2-7.8 One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography(IMAC). Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel co-ordination, freeing the His-tagged proteins. Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, which stimulates the central nervous system. It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities.


References

Storrie, B., et al. (1990). Meth. Enzymol. 182, 217.

Physical State :
Solid
Solubility :
Soluble in water (633 g/L) at 20° C, acetone, chloroform, pyridine, alcohol, ether. Slightly soluble in benzene. Very slightly soluble in petroleum ether.
Storage :
Store at room temperature
Melting Point :
89-91° C
Boiling Point :
256° C
Density :
1.03 g/cm3 at 20° C
Refractive Index :
n20D 1.53
IC50 :
Nitric oxide synthase, inducible: IC50 = 40 µM (Mus musculus); Thromboxane-A synthase: IC50 = 670 µM (human)
Ki Data :
Nitric-oxide synthase, brain: Ki= 175 µM (human)
pK Values :
pKa: 6.95 (25° C), 13.89, pKb: 7.18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
NI3325000
Transport :
UN 3263, Class 8, Packing group II
PubChem CID :
795
Merck Index :
14: 4912
MDL Number :
MFCD00005183
EC Number :
206-019-2
Beilstein Registry :
103853
SMILES :
N1C=CN=C1

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Imidazole  Product Citations

See how others have used Imidazole. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27847172  Desuzinges Mandon, E. et al. 2017. Anal. Biochem. 517: 40-49.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Good quality chemical Good quality chemical
Date published: 2015-10-06
Rated 5 out of 5 by from Using for our publication and we are very pleased Using for our publication and we are very pleased.
Date published: 2015-04-08
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