Imetit dihydrobromide is an effective, high-affinity H3 and H4 histamine receptor agonist with Ki values of 0.3 and 2.7 nM, respectively. This compound initiates an eosinophil shape change (EC50 = 25 nM). Imetit dihydrobromide is equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.
1. Garbarg, M., et al. 1992. J. Pharmacol. Exp. Ther. 263: 304-310. 2. Farzin, D. and Attarzadeh, M. 2000. Eur. J. Pharmacol. 404: 169-174. 3. Ling, P., et al. 2004. Br. J. Pharmacol. 142: 161-171.
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