Imetit dihydrobromideA high affinity agonist at the histamine H3- and H4-receptors

Imetit dihydrobromide (CAS 32385-58-3)

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Synonym: S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Application: A high affinity agonist at the histamine H3- and H4-receptors
CAS Number: 32385-58-3
Purity: ≥98%
Molecular Weight: 332.06
Molecular Formula: C6H10N4S•2HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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Imetit dihydrobromide is an effective, high-affinity H3 and H4 histamine receptor agonist with Ki values of 0.3 and 2.7 nM, respectively. This compound initiates an eosinophil shape change (EC50 = 25 nM). Imetit dihydrobromide is equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.


References

1. Garbarg, M., et al. 1992. J. Pharmacol. Exp. Ther. 263: 304-310.
2. Farzin, D. and Attarzadeh, M. 2000. Eur. J. Pharmacol. 404: 169-174.
3. Ling, P., et al. 2004. Br. J. Pharmacol. 142: 161-171.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM). Insoluble in acetone.
Storage :
Store at room temperature
Melting Point :
206-207° C
Boiling Point :
430.8° C
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
Histamine H3 receptor: EC5050 = 1 nM (rat); Histamine H3 receptor: IC50 = 1.9 nM (human); Histamine H3 Receptor: IC50 = 4.6 nM (human); shape change : EC5050 = 25 nM (eosinophils )
Ki Data :
Histamine H3 Receptor: Ki= 0.3 nM; Histamine H3 Receptor: Ki= 0.57 nM (human); Histamine H4 receptor: Ki= 1.6 nM (human); Histamine H4 Receptor: Ki= 2.7 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
FD3086000
PubChem CID :
11957573
MDL Number :
MFCD00153816
SMILES :
C1=C(NC=N1)CCSC(=N)N.Br.Br

Download SDS (MSDS)

Certificate of Analysis

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