IKK-2 Inhibitor XIA potent and cell-permeable inhibitor of IKK beta (IKK-2) that is thought to target the ATP-binding pocket

IKK-2 Inhibitor XI (CAS 354810-80-3)

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Synonym: 3-(Carbamoylamino)-5-Phenylthiophene-2-Carboxamide
Application: A potent and cell-permeable inhibitor of IKK beta (IKK-2) that is thought to target the ATP-binding pocket
CAS Number: 354810-80-3
Molecular Weight: 261.30
Molecular Formula: C12H11N3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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A cell-permeable thiophenecarboxamide-ureido compound that exhibits potent, ATP-binding pocket-targeting inhibitor of IKK beta (IKK-2). Affects IKK alpha (IKK-1) and JNK1 only at much higher concentrations. Shown to reduce LPS-induced TNF-α production in PBMCs and exhibit oral

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
IC50 :
IKKβ: IC50 = 25 nM; IKKα: IC50 = 1.0 µM; JNK1: IC50 = 1.6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10220851
SMILES :
C1=CC=C(C=C1)C2=CC(=C(S2)C(=O)N)NC(=O)N

Download SDS (MSDS)

Certificate of Analysis

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