IBC 293 A cell permeable Niacin triazolo derivative that is a selective agonist towards the human orphan G-protein-coupled receptor GPR109b/HM74.

IBC 293  (CAS 306935-41-1)

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Application: A selective GPR109b/HM74 receptor agonist
CAS Number: 306935-41-1
Molecular Weight: 205.2
Molecular Formula: C10H11N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
IBC 293 sc-203079 25 mg $200.00

IBC 293 is a cell permeable Niacin triazolo derivative that is a selective agonist towards the human orphan G-protein-coupled receptor GPR109b/HM74. In addition, IBC 293 inhibits forskolin (sc-3562) and isoproterenol (sc-202188) in GPR109b-expressing CHO cells and human adipocytes. The inhibition of forskolin and isoproterenol also causes a reduction in cAMP levels in both cell lines. It has been reported that GPR 109b occurs as homodimers and heterodimers in which the extent of homo-dimerization and hetero-dimerization does not depend on ligand binding.


References

1. Mandrika, I., et al. 2010. Biochem. Biophys. Res. Commun. 395: 281-287. PMID: 20380810

Physical State :
Solid
Solubility :
DMSO or EtOH
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2736690
SMILES :
CC(C)N1C2=C(C=C(C=C2)C(=O)O)N=N1

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Certificate of Analysis

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