|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
|IBC 293||sc-203079||25 mg||$200.00||
IBC 293 is a cell permeable Niacin triazolo derivative that is a selective agonist towards the human orphan G-protein-coupled receptor GPR109b/HM74. In addition, IBC 293 inhibits forskolin (sc-3562) and isoproterenol (sc-202188) in GPR109b-expressing CHO cells and human adipocytes. The inhibition of forskolin and isoproterenol also causes a reduction in cAMP levels in both cell lines. It has been reported that GPR 109b occurs as homodimers and heterodimers in which the extent of homo-dimerization and hetero-dimerization does not depend on ligand binding.
1. Mandrika, I., et al. 2010. Biochem. Biophys. Res. Commun. 395: 281-287. PMID: 20380810
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