Hypoxanthine A marker for energy perturbation in hypoxia/ ischemia

Hypoxanthine (CAS 68-94-0)

Hypoxanthine | CAS 68-94-0 is rated 5.0 out of 5 by 1.
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Synonym: 6-Hydroxypurine; Sarcine;Purin-6-ol
Application: A marker for energy perturbation in hypoxia/ ischemia
CAS Number: 68-94-0
Purity: ≥99%
Molecular Weight: 136.11
Molecular Formula: C5H4N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hypoxanthine can be used as a marker for energy perturbation in hypoxia/ischemia and is structurally related to 6-mercaptopurine. The compound has been used in studies as in indicator, along with uric acid (sc-213135) and allantoin (sc-207271), of in vivo free radical reactions. To understand its biological implications, hypoxanthine has been used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol α (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus.


References

1. Marklund, N., et al. 2000. Acta Neurochir. 142: 1135-1141. PMID: 11129536
2. Patro, J.N., et al. 2009. Biochemistry. 48: 8271-8278. PMID: 19642651
3. Malináková, K., et al. 2010. J Phys Chem A. 114: 1985-1995. PMID: 20055404
4. Sun, X. and Lee, J.K. 2010. J. Org. Chem. 75: 1848-1854. PMID: 20184296

Usage :
Sterilize by filtration through a 0.22 µm filter.
Appearance :
Powder
Physical State :
Solid
Solubility :
Does not mix appreciably with water (1:1400). Small octahedra crystals from water.
Storage :
Store at room temperature
Melting Point :
>300° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UP0791000
PubChem CID :
790
Merck Index :
14: 4869
MDL Number :
MFCD00005725
Beilstein Registry :
2081
SMILES :
C1=NC2=C(N1)C(=O)N=CN2

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Hypoxanthine  Product Citations

See how others have used Hypoxanthine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 15811855  Druzhyna, NM. et al. 2005. J. Biol. Chem. 280: 21673-21679.

PMID: # 15452132  Jana, A. et al. 2004. J. Biol. Chem. 279: 51451-51459.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Jana et Jana et. al. (PubMed ID 15452132) found that they were able to induce the activation of N-SMase when treating with both hypoxanthine and xanthine oxidase. No activation of N-SMase was observed when treating with only one compound. -SCBT Publication Review
Date published: 2015-01-27
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