Hypoestoxide, Hypoestes rosea is a naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Hypoestoxide, Hypoestes rosea is a selective and direct IKK (IκB kinase) inhibitor in TNF-α stimulated HeLa cells, which prevents NF-κB activation. Hypoestoxide, Hypoestes rosea also inhibits the nitric oxide production by IL-1β or IL-17 stimulated chondrocytes.
1. Ojo-Amaize, E A., et al., 2001. Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cellular immunology. 209(2): 149-57. PMID: 11446747
2. Ojo-Amaize, Emmanuel A., et al., 2002. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer research. 62(14): 4007-14. PMID: 12124334
3. Pulai, Judit I., et al., 2005. NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. Journal of immunology (Baltimore, Md. : 1950). 174(9): 5781-8. PMID: 15843581
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