Hymenidin Hymenidin is an antagonist of serotonergic receptors and has antiprotozoal activity. Additionally, hymenidin inhibits Cdk5/p35 and GSK-3β.

Hymenidin  (CAS 107019-95-4)

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Synonym: 2-Debromooroidin
Application: An antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3β
CAS Number: 107019-95-4
Purity: ≥95%
Molecular Weight: 310.2
Molecular Formula: C11H12BrN5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Hymenidin sc-202177 1 mg $258.00

Hymenidin is an antagonist of serotonergic receptors and has antiprotozoal activity. Additionally, hymenidin inhibits Cdk5/p35 (IC50 = 4 μM) and GSK-3β (IC50 = 12 μM).


References

1. Kobayashi, J., et al., 1986. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 42(10): 1176-7. PMID: 3770140
2. Meijer, L., et al., 2000. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & biology. 7(1): 51-63. PMID: 10662688
3. Bickmeyer, Ulf., et al., 2004. Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon : official journal of the International Society on Toxinology. 44(1): 45-51. PMID: 15225561

Physical State :
Solid
Derived From :
Hymeniacidon sp.
Solubility :
Soluble in DMSO, and 100 % ethanol.
Storage :
Store at -20° C
Melting Point :
249.17° C (Predicted)
Boiling Point :
578.30° C (Predicted)
Density :
1.69 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
Cdk5/p35: IC50 = 4 µM; GSK-3β: IC50 = 12 µM; Plasmodium f.: IC50 = 40.43 µM; Leishmania d.: IC50 = 96.29 µM; Trypanosoma c.: IC50 = 235.65 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6439099
MDL Number :
MFCD08702701
SMILES :
C1=C(NC=C1Br)C(=O)NCC=CC2=CN=C(N2)N

Download SDS (MSDS)

Certificate of Analysis

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