Hymeglusin An irreversible HMG-CoA synthase inhibitor

Hymeglusin (CAS 29066-42-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 50ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An irreversible HMG-CoA synthase inhibitor
CAS Number: 29066-42-0
Purity: >95%
Molecular Weight: 324.4
Molecular Formula: C18H28O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Hymeglusin is a fungal β-lactone cell wall-targeting antibiotic that irreversibly inhibits cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase by covalently modifying the active Cys 129 residue of the enzyme. Studies show that hymeglusin can be inhibited by the (2R, 3R)-isomer of β-lactone trans-DU-6622 because this lactone binds to the same site on HMG-CoA synthase as hymeglusin. In addition, hymeglusin suppresses the translation of cWRA in Staphylococcus aureus, which codes for a polypepetide that responds to cell wall inhibition.


References

1. Tomoda, H., et al. 1999. Biochem. Biophys. Res. Commun. 265: 536-540. PMID: 10558904
2. Tomoda, H., et al. 2004. Biochim. Biophys. Acta. 1636: 22-28. PMID: 14984735
3. Balibar, C.J., et al. 2010. Microbiology. 156: 1372-1383. PMID: 20167623

Physical State :
Solid
Derived From :
Scopulariopsis sp. F-244.
Solubility :
Soluble in methanol, 100% ethanol, DMSO (0.90-1.10 mg/ml), and chloroform. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
196.60° C (Predicted)
Boiling Point :
516.58° C at 760 mmHg (Predicted)
Density :
1.10 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
pK Values :
pKa: 4.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
YQ1170000
PubChem CID :
6440895
MDL Number :
MFCD01940046
SMILES :
C[C@H](CCCC[C@@H]1[C@H](C(=O)O1)CO)C/C(=C/C(=C/C(=O)O)/C)/C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Hymeglusin  Product Citations

See how others have used Hymeglusin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26698156  Stäubert, C. et al. 2016. Med. Oncol. 33: 6.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 58ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.