HU-331 is a hydroxylquinone cannabidiol analog that exhibits potent antineoplastic activity on a variety of human cancer cell lines. HU-331 is an inhibitor of Topo II.
1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Current Medicinal Chemistry 6 635-664 (1999). 2 Martin, B.R., Mechoulam, R., Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999). 3 Kogan, N.M., Rabinowitz, R., Levi, P., et al. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. J Med Chem 47 3800-3806 (2004).
Solution in methyl acetate
Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), 1 solution of ethanol:PBS (pH 7.2) (~0.5 mg/ml), and water (0.5 mg/ml).
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