HPI-4

HPI-4 (CAS 302803-72-1)

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Synonym: Ciliobrevin A
Application: A Hedgehog pathway inhibitor
CAS Number: 302803-72-1
Purity: ≥98%
Molecular Weight: 358.18
Molecular Formula: C17H9Cl2N3O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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HPI-4 is a Hedgehog pathway inhibitor and ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics and HPI-4 blocks Sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM) downstream of Smo. It also inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.


References

1. Hyman, Joel M., et al., 2009. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences of the United States of America. 106(33): 14132-7. PMID: 19666565

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml).
Storage :
Store at 4° C
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Sonic hedgehog (Shh)-induced hedgehog pathway activation: IC50 = 7 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
6883982
MDL Number :
MFCD01911757
SMILES :
C1=CC=C2C(=C1)C(=O)N/C(=C(\C#N)/C(=O)C3=C(C=C(C=C3)Cl)Cl)/N2

Download SDS (MSDS)

Certificate of Analysis

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