HNMPA-(AM)3 is a cell-permeable analog of HNMPA (sc-205714) that yields the parent compound via cleavage by cytosolic esterases. HNMPA-(AM)3 acts as an insulin R (Insulin receptor tyrosine kinase) inhibitor. It has also been shown to inhibit tyrosine autophosphorylation of the human insulin receptor.
1. Saperstein, R., et al. 1989. Biochemistry. 28: 5694-5701. PMID: 2550060
2. Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 7885-7889. PMID: 1381504
Soluble in DMSO (20 mg/ml), and ethanol (20 mg/ml).
I have received the product sc-221730 but there was no datasheet included, only material safety datasheet. Could you provide me the datasheet in order for me to dissolve the lyophilized product.
Thanks in advance
Asked by: Yeliz Yilmaz
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis. You may request a lot-specific Certificate Of Analysis on our website. This chemical, HNMPA-(AM)3 (CAS 120944-03-8), is soluble in DMSO (> 20 mg/ml) or 100% ethanol (> 20 mg/ml).
Rated 5 out of
Choi KH;et alChoi KH;et al. (PubMed ID: 25761600) demonstrated that the neuroproliferation effects of alpha-lipoic acid was inhibited by HNMPA (AM)3 (insulin receptor inhibitor) in rats. -SCBT Publication Review
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