Histone Lysine Methyltransferase Inhibitor (BIX-01294) is a G9a (histone lysine methyltransferase (HMTase)) inhibitor, specifically shown to inhibit the G9a-mediated generation of H3K9me2 (histone H3 lysine 9 dimethylation), not competitive with the S-adenosyl-methionine cofactor. Levels of H3K9me2 are restored with removal of BIX-01294. This molecule allows transient modulation of HMTase behavior, providing a tool for studying consequent effects on gene expression and chromatin organization. Histone Lysine Methyltransferase Inhibitor is an inhibitor of EHMT.
1. Kubicek, Stefan., et al., 2007. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Molecular cell. 25(3): 473-81. PMID: 17289593 2. Shi, Yan., et al., 2008. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell stem cell. 2(6): 525-8. PMID: 18522845 3. Huangfu, Danwei., et al., 2008. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature biotechnology. 26(7): 795-7. PMID: 18568017
Soluble in water (100 mM), DMSO (5 mg/ml), and ethanol.
How is this manufactured – synthetically or has an animal/human been used to obtain the chemical? We need to know to get the correct customs form for importation to Australia.
Asked by: AnitaP
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Rated 5 out of
Shi et alShi et al. (PubMed ID 18522845) used Histone Lysine Methyltransferase Inhibitor (BIX-01294) to inhibit G9a histone methyltrasferase and found this to improve reprograming efficiency in neural progenitor cells transduced with Oct3/4-Klf4. -SCBT Publication Review
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