Hispolon A polyphenolic compound that induces ROS-mediated apoptosis

Hispolon

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Synonym: (3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxy-hexa-3,5-dien-2-one
Application: A polyphenolic compound that induces ROS-mediated apoptosis
Purity: ≥98%
Molecular Weight: 220.2
Molecular Formula: C12H12O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hispolon is a polyphenolic compound that induces ROS-mediated apoptosis. Has antiviral activity.


References

Inhibition of chemiluminescence response of human mononuclear cells and suppression of mitogen-induced proliferation of spleen lymphocytes of mice by hispolon and hispidin: N.A. Ali, et al.; Pharmazie 51, 667 (1996) Antiviral activity of Inonotus hispidus: N.A. Awadh Ali, et al.; Fitoterapia 74, 483 (2003) Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway: W. Chen, et al.; Free Radic. Biol. Med. 45, 60 (2008)

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
Melting Point :
155.65° C (Predicted)
Boiling Point :
~477.21° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67
IC50 :
KETR3 (Renal carcinoma cells): IC50 = 206 nM (human); MCF7 (Breast carcinoma cells): IC50 = 25 nM (human); A549 (Lung carcinoma cells): IC50 = 183 nM (human)
pK Values :
pKa: 8.35
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10082188
SMILES :
CC(=O)C=C(C=CC1=CC(=C(C=C1)O)O)O

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Certificate of Analysis

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Hispolon  Product Citations

See how others have used Hispolon. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26056942  Jang, EH. et al. 2015. Biochem. Biophys. Res. Commun. 463: 917-22.

PMID: # 25442286  Hsieh, MJ. et al. 2014. Phytomedicine. 21: 1746-52.

PMID: # 24093560  Hsiao, PC. et al. 2013. J. Agric. Food Chem. 61: 10063-73.

Citations 1 to 3 of 3 total
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