HexylHIBOA group I mGluR antagonist

HexylHIBO (CAS 334887-43-3)

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Application: A group I mGluR antagonist
CAS Number: 334887-43-3
Purity: >98%
Molecular Weight: 256.3
Molecular Formula: C12H20N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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HexylHIBO is a group I mGluR antagonist. Group I mGluR include types mGluR-1 and mGluR-5. In vitro, this compound decreases sEPSCs in rat pyramidal neurons. Group I (mGluR-1 and mGluR-5) receptors are coupled to Gq/11 and are activators of phospholipase C.


References

1. Madsen, U., et al. 2001. J. Med. Chem. 44: 1051-1059.
2. Bandrowski, A.E., et al. 2003. J. Neurophysiol. 89: 1308-1316.

Solubility :
Soluble to 20 mM in 1eq. NaOH
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6604908
SMILES :
CCCCCCC1=C(ONC1=O)CC(C(=O)O)N

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Certificate of Analysis

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