Heptelidic acid An inhibitor of GAPDH and certain DNA polymerases

Heptelidic acid (CAS 74310-84-2)

Heptelidic acid | CAS 74310-84-2 is rated 5.0 out of 5 by 1.
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Synonym: Koningic acid
Application: An inhibitor of GAPDH and certain DNA polymerases
CAS Number: 74310-84-2
Molecular Weight: 280.32
Molecular Formula: C15H20O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Heptelidic acid is a potent and selective GAPDH (glyceraldehyde 3-phosphate dehydrogenase) inhibitor. Suggested to act by binding to the essential Cys149 residue in the catalytic site of GADPH. Heptelidic acid is an apoptosis inhibitor that displays antibiotic, anticancer, and anitmalarial properties. A selective and competitive inhibitor of the mammalian DNA polymerases: DNA pol β, DNA pol λ and TdT (terminal deoxynucleotidyl transferase).

Physical State :
Solid
Derived From :
Trichoderma sp.
Solubility :
Soluble in ethanol, DMSO, methanol, and water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Beilstein Registry :
5091359
SMILES :
CC(C)C2CCC1(CO1)[C@@H]3[C@@H]2C=C(COC3=O)C(=O)O[H]

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Certificate of Analysis

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Date published: 2015-03-30
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