Heptelidic acid is a potent and selective GAPDH (glyceraldehyde 3-phosphate dehydrogenase) inhibitor. Suggested to act by binding to the essential Cys149 residue in the catalytic site of GADPH. Heptelidic acid is an apoptosis inhibitor that displays antibiotic, anticancer, and anitmalarial properties. A selective and competitive inhibitor of the mammalian DNA polymerases: DNA pol β, DNA pol λ and TdT (terminal deoxynucleotidyl transferase).
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