Hemin chloride A porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control

Hemin chloride (CAS 16009-13-5)

Hemin chloride | CAS 16009-13-5 is rated 5.0 out of 5 by 1.
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| See product citations (1)
Synonym: Teichmann's crystals; Ferriheme chloride; Chloroferriprotoporphyrin
Application: A porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control
CAS Number: 16009-13-5
Purity: ≥95%
Molecular Weight: 651.94
Molecular Formula: C34H32ClFeN4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Hemin chloride sc-202646 5 g $88.00
Hemin chloride sc-202646A 10 g $144.00
Hemin chloride sc-202646B 25 g $304.00

Hemin chloride, a heme oxygenase 1 inducer, is a porphyrin complex. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-κB, hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare agar medium for the cultivation of distinct bacteria.


References

1. Taher, M.M., et al. 1987. Arch. Biochem. Biophys. 257: 100-106. PMID: 2820306
2. Funanage, V.L., et al. 1989. J. Cell. Physiol. 141: 591-597. PMID: 2592428
3. Wolf, H.U., et al. 1992. Biol. Chem. Hoppe-Seyler. 373: 305-313. PMID: 1515057
4. Liu, H., et al. 1999. J. Clin. Invest. 103: 963-970. PMID: 10194468
5. Yoneya, R., et al. 2000. Toxicol. Lett. 116: 223-229. PMID: 10996484
6. Uc, A., et al. 2005. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G202-G208. PMID: 15805100
7. Hasan, R.N., et al. 2008. Circ. Res. 102: 42-50. PMID: 17967787
8. Fouad, A.A., et al. 2009. Toxicology. 257: 153-160. PMID: 19150641

Physical State :
Solid
Derived From :
Derived from porcine
Solubility :
Soluble in dilute ammonia water, and 0.1-1.0 N NaOH. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
>300° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LJ8080000
PubChem CID :
455658
Merck Index :
14: 4644
MDL Number :
MFCD00010726
EC Number :
240-140-1
Beilstein Registry :
5229914
SMILES :
CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O.[Cl-].[Fe+3]

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Certificate of Analysis

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See how others have used Hemin chloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 12453873  Alam, J. et al. 2003. Am. J. Physiol. Renal Physiol. 284: F743-F752.

Citations 1 to 1 of 1 total

What is the shipping temperature of this product?

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This chemical, Hemin chloride (CAS 16009-13-5), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Alam Alam, J. et al. (PubMed 12453873) used Hemin chloride to investigate the mechanism by which it activates the oxygenase-1 gene. They found that Hemin chloride promotes stabilization of Nrf2, leading to accumulation of Nrf2-MafG dimers that bind to StREs to activate the oxygenase-1 gene. -SCBT Publication Review
Date published: 2015-01-09
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