HDAC6 Inhibitor An inhibitor of HDAC6

HDAC6 Inhibitor (CAS 1045792-66-2)

HDAC6 Inhibitor | CAS 1045792-66-2 is rated 5.0 out of 5 by 2.
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Synonym: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester
Application: An inhibitor of HDAC6
CAS Number: 1045792-66-2
Purity: ≥95%
Molecular Weight: 446.50
Molecular Formula: C22H30N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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HDAC6 Inhibitor is a selective and potent inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with HDAC1 (IC50 = 271 nM), HDAC2 (IC50 = 252 nM), HDAC3 (IC50 = 0.42 nM), HDAC8 (IC50 = 6851 nM), and HDAC10 (IC50 = 90.7 nM). HDAC6 Inhibitor also prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). HDAC6 Inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroamic acid (sc-220139).


References

1. Kozikowski, Alan P., et al., 2008. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. Journal of medicinal chemistry. 51(15): 4370-3. PMID: 18642892

Physical State :
Solid
Solubility :
Soluble in DMSO (~15 mg/ml), and DMF (~15 mg/ml).
Storage :
Store at -20° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
HDAC 6: IC50 = 0.002 nM; HDAC 1: IC50 = 271 nM; HDAC 2: IC50 = 252 nM; HDAC 3: IC50 = 0.42 nM; HDAC 8: IC50 = 6851 nM; HDAC 10: IC50 = 90.7 nM; growth of several pancreatic cancer cell lines: IC50 = 0.1-1 µM
pK Values :
pKa: 8.12, pKb: 2.41
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24951314
SMILES :
CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO

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Certificate of Analysis

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HDAC6 Inhibitor  Product Citations

See how others have used HDAC6 Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28767685  Takano, K. et al. 2017. PLoS ONE. 12: e0182291.

PMID: # 27363897  Janjanam, J. et al. 2016. Sci Rep. 6: 28687.

PMID: # 25342559  Yang, Y. et al. 2014. Cell Res. 24: 1342-53.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from It performed properly in our human cell culture It performed properly in our human cell culture.
Date published: 2015-09-29
Rated 5 out of 5 by from Kozikowski et al Kozikowski et al. (PubMed ID 18642892) used HDAC6 to inhibit histone deacetylase HDAC6. -SCBT Publication Review
Date published: 2015-04-08
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