HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.
1. Hershko, C., et al. 1984. J. Lab. Clin. Med. 103: 337-346. PMID: 6699459 2. Rollet-Labelle, E., et al. 1998. Free Radic. Biol. Med. 24: 563-572. PMID: 9559868 3. Gozin, A., et al. 1998. Free Radic. Biol. Med. 25: 1021-1032. PMID: 9870555 4. Faller, B., et al. 2000. J. Med. Chem. 43: 1467-1475. PMID: 10780902 5. Samuni, A.M., et al. 2001. Free Radic. Biol. Med. 30: 170-177. PMID: 11163534
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) at 40° C, and water (4 mg/ml) at 50° C (with vigorous agitation approximately 15 minutes).
Store at room temperature
pKa: 1.77, 8.03
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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please send me certification for chelate HBED.
and send me Comparison among chelates HBED with EDDHMA and EDTA
Asked by: meysam
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