HBED An iron chelator and hydroxyl radical inhibitor

HBED (CAS 35369-53-0)

HBED | CAS 35369-53-0 is rated 5.0 out of 5 by 1.
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Synonym: N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride
Application: An iron chelator and hydroxyl radical inhibitor
CAS Number: 35369-53-0
Purity: ≥95%
Molecular Weight: 424.89
Molecular Formula: C20H24N2O6•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.


References

1. Hershko, C., et al. 1984. J. Lab. Clin. Med. 103: 337-346. PMID: 6699459
2. Rollet-Labelle, E., et al. 1998. Free Radic. Biol. Med. 24: 563-572. PMID: 9559868
3. Gozin, A., et al. 1998. Free Radic. Biol. Med. 25: 1021-1032. PMID: 9870555
4. Faller, B., et al. 2000. J. Med. Chem. 43: 1467-1475. PMID: 10780902
5. Samuni, A.M., et al. 2001. Free Radic. Biol. Med. 30: 170-177. PMID: 11163534

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) at 40° C, and water (4 mg/ml) at 50° C (with vigorous agitation approximately 15 minutes).
Storage :
Store at room temperature
Melting Point :
130-134° C
Refractive Index :
n20D 1.65
pK Values :
pKa: 1.77, 8.03
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
66848913
MDL Number :
MFCD04113603
SMILES :
C1=CC=C(C(=C1)CN(CCN(CC2=CC=CC=C2O)CC(=O)O)CC(=O)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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hello please send me certification for chelate HBED. and send me Comparison among chelates HBED with EDDHMA and EDTA tanks

Asked by: meysam
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-08-16
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Rated 5 out of 5 by from Samuni et al Samuni et al. (PubMed ID 11163534) showed that HBED was a hydrogen-donating antioxidant and an effective iron chelator. -SCBT Publication Review
Date published: 2015-02-20
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