Hassallidin A

Hassallidin A

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Application: A broad spectrum antifungal compound
Purity: ≥98%
Molecular Weight: 1382.51
Molecular Formula: C62H99N11O24
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hassallidin A is a broad spectrum antifungal compound with activity against Candida, Acremonium, Cryptococcus neoformans, Trichosporon, Aspergillus, Fusarium sambucium (minimal inhibition concentration (MIC) range: 4-16 μg/ml). Hassallidin A shows moderate activity against cancerous cells (Jurkat ATCC-TIB-152, L 929), but no antibacterial activity (Bacillus subtilis, Streptomyces versicolor, Escherichia coli).


References

1. Neuhof, Torsten., et al., 2005. Hassallidin A, a glycosylated lipopeptide with antifungal activity from the cyanobacterium Hassallia sp. Journal of natural products. 68(5): 695-700. PMID: 15921412
2. Neuhof, Torsten., et al., 2006. Hassallidin B--second antifungal member of the Hassallidin family. Bioorganic & medicinal chemistry letters. 16(16): 4220-2. PMID: 16777415
3. Neuhof, Torsten., et al., 2006. Comparison of susceptibility and transcription profile of the new antifungal hassallidin A with caspofungin. Biochemical and biophysical research communications. 349(2): 740-9. PMID: 16949033

Physical State :
Solid
Derived From :
Hassallia
Solubility :
Soluble in 100% ethanol, methanol or DMSO; insoluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3462, Class 6.1, Packing group II
PubChem CID :
44583981
SMILES :
CCCCCCCCCCCC(C(C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1[C@H](OC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)CNC(=O)[C@@H](NC(=O)/C(=C/C)/NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)CC2=CC=C(C=C2)O)CCC(=O)N)C)[C@@H](C)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)CCC(=O)N)C)O)O

Download SDS (MSDS)

Certificate of Analysis

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