Harpagoside An antiinflammatory inhibitor of NF-kappaB activation

Harpagoside (CAS 19210-12-9)

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Application: An antiinflammatory inhibitor of NF-kappaB activation
CAS Number: 19210-12-9
Purity: ≥98%
Molecular Weight: 494.5
Molecular Formula: C24H30O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Harpagoside sc-203073 5 mg $76.00
Harpagoside sc-203073A 25 mg $400.00

Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil's Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.


References

1. García, D., et al. 1996. Farmaco. 51: 443-446. PMID: 8766229
2. Chantre, P., et al. 2000. Phytomedicine. 7: 177-183. PMID: 11185727
3. Kaszkin, M., et al. 2004. Phytomedicine. 11: 585-595. PMID: 15636171
4. Huang, T.H., et al. 2006. J Ethnopharmacol. 104: 149-155. PMID: 16203115
5. Günther, M., et al. 2006. Phytochem Anal. 17: 1-7. PMID: 16454469
6. Abdelouahab, N. and Heard, C. 2008. J. Nat. Prod. 71: 746-749. PMID: 18412394
7. Ouitas, N.A. and Heard, C. 2010. Phytother Res. 24: 333-338. PMID: 19610038

Physical State :
Solid
Derived From :
Scrophularia ningpoensis Hemsl (Figwort)
Solubility :
Soluble in methanol.
Storage :
Store at -20° C
Refractive Index :
n20/D 1.659
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5281542
MDL Number :
MFCD00017415
EC Number :
242-881-6
SMILES :
CC1(CC(C2(C1C(OC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O)OC(=O)C=CC4=CC=CC=C4

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Certificate of Analysis

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What is the physical appearance?

Asked by: Jz28sail
Thank you for your question. Harpagoside is expected to be a white to off-white powder.
Answered by: Technical Support
Date published: 2017-03-27
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