GW 842166XAn agonist of the CB2 receptor

GW 842166X (CAS 666260-75-9)

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Synonym: 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Application: An agonist of the CB2 receptor
CAS Number: 666260-75-9
Molecular Weight: 449.3
Molecular Formula: C18H17Cl2F3N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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GW 842166X is a CB2 receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively.2 When administered orally to rats in the Freund's complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and f


References

1 Khanolkar, A.D., Lu, D., Ibrahim, M., et al. Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem 50 6493-6500 (2007). 2 Giblin, G.M.P., O'Shaughnessy, C.T., Naylor, A., et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem 50(11) 2597-2600 (2007).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10253143
SMILES :
C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C=C(C=C3)Cl)Cl

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Certificate of Analysis

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