GW 842166X is a CB2 receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively.2 When administered orally to rats in the Freund's complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and f
1 Khanolkar, A.D., Lu, D., Ibrahim, M., et al. Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem 50 6493-6500 (2007). 2 Giblin, G.M.P., O'Shaughnessy, C.T., Naylor, A., et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem 50(11) 2597-2600 (2007).
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