Guanylyl Cyclase synthesizes cGMP from GTP when activated by low intracellular Ca2+ levels. It is also the primary receptor for nitric oxide (NO) and is activated when bound by NO.
1. Humbert, P., et al., 1990. Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method. European journal of biochemistry / FEBS. 190(2): 273-8. PMID: 1973095
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