Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt is a Gβ-activating (G-protein-activating) GTP analog, which is more resistant to hydrolysis than GTP.

Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt  (CAS 94825-44-2)

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Synonym: GTP-γ-S 4Li
Application: A G-protein-activating GTP analog
CAS Number: 94825-44-2
Molecular Weight: 562.98
Molecular Formula: C10H12N5O13P3S•4Li
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt sc-202639 10 mg $278.00

Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt is a Gβ-activating (G-protein-activating) GTP analog, which is more resistant to hydrolysis than GTP. Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.


References

1.Lino, S., et al. 2000. FEBS Lett. 479, 46. 2.Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182. 3.Hess, S.D., et al. 1993. Science 259, 1169. 4.Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183. 5.McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117. Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66. 6.Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466. 7.Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615. 8.Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (≥75 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.95 (Predicted)
Ki Data :
Kappa opioid receptor: Ki= 0.0048 nM (human)
pK Values :
pKa: 0.97 (Predicted), pKb: 2.42 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44134755
MDL Number :
MFCD00135151
EC Number :
305-606-1
Beilstein Registry :
8182249
SMILES :
[Li+].[Li+].[Li+].[Li+].NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]2O)C(=O)N1

Download SDS (MSDS)

Certificate of Analysis

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