Guanosine 3prime5prime-cyclic Monophosphate, Sodium Salt An agent that interacts with the extracellular signals NO

Guanosine 3′5′-cyclic Monophosphate, Sodium Salt (CAS 40732-48-7)

Guanosine 3′5′-cyclic Monophosphate, Sodium Salt, CAS 40732-48-7 is rated 5.0 out of 5 by 1.
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Synonym: Cyclic GMP; 3′,5′-Cyclic GMP monosodium salt; 3′,5′-cGMP-Na
Application: An agent that interacts with the extracellular signals NO
CAS Number: 40732-48-7
Purity: >98%
Molecular Weight: 367.19
Molecular Formula: C10H11N5O7P•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Guanosine 3′,5′-cyclic Monophosphate, also known as cGMP, is an important intracellular second messenger that has been shown to interact with the extracellular signals nitric oxide and natriuretic peptides, as well as mediate their action. cGMP interacts with the receptors cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. The compound can activate protein kinase G, and it has been shown that elevated levels of cGMP in vivo stimulates cGMP-dependent protein kinase (PKG). Research shows that cGMP can suppress apoptosis in rat ovarian follicles, and that it is metabolized quickly in the presence of corresponding phosphodiesterases.


References

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4. Zagotta, W.N., et al. 1996. Annu. Rev. Neurosci. 19: 235-263. PMID: 8833443
5. Finn, J.T., et al. 1996. Annu. Rev. Physiol. 58: 395-426. PMID: 8815801
6. Vaandrager, A.B., et al. 1996. Mol. Cell. Biochem. 157: 23-30. PMID: 8739225
7. Wang, X. and Robinson, P.J. 1997. J. Neurochem. 68: 443-456. PMID: 9003029
8. Lohmann, S.M., et al. 1997. Trends Biochem. Sci. 22: 307-312. PMID: 9270304
9. Browning, D.D., et al. 1999. J. Biol. Chem. 274: 537-542. PMID: 9867877 10. Bevans, C.G., et al. 1999. J. Biol. Chem. 274: 3720-3725. PMID: 9920924

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D ~2.06 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23702131
Merck Index :
14: 2709
MDL Number :
MFCD00038424
EC Number :
255-056-0
Beilstein Registry :
6467425
SMILES :
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3NC(=NC4=O)N)O)OP(=O)(O1)[O-].[Na+]

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Certificate of Analysis

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Rated 5 out of 5 by from Yeh JL; et al Yeh JL; et al. (PubMed ID: 20132211)determined that Guanosine 3 5 -cyclic Monophosphate, Sodium Salt was increased in isoprenaline (ISO)-induced cardiac hypertrophy in rats. -SCBT Publication Review
Date published: 2015-03-21
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