GSK-3beta Inhibitor I A thiadiazolidinone analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β

GSK-3β Inhibitor I (CAS 327036-89-5)

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Synonym: TDZD-8; 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Application: A thiadiazolidinone analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β
CAS Number: 327036-89-5
Purity: 95%
Molecular Weight: 222.26
Molecular Formula: C10H10N2SO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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GSK-3β Inhibitor I is a thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). GSK-3β Inhibitor I inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5 µM and 673 nM, respectively). GSK-3β Inhibitor I does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). This compound binds to the active site of GSK-3β.

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4124851
SMILES :
C1(N(C(=O)SN1C)CC2=CC=CC=C2)=O

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Certificate of Analysis

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