GSK-3 Inhibitor XVI is a cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). CHIR99021 exhibits little to no activity toward 46 other enzymes (IC50 >8.8 μM against 20 kinases and Ki ≥5 μM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 μM).
Soluble in DMSO (10 mg/ml), water (<1 mg/ml) at 25° C, and ethanol (<1 mg/ml) at 25° C.
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Rated 5 out of
Various publications have cited GSKVarious publications have cited GSK-3 Inhibitor XVI as a potent, cell-permeable aminopyrimidine compound shown to selectively inhibit GSK-3, with little effect on similar enzymes. -SCBT Publication Review
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