Griseofulvin An antifungal and antiproliferative agent that affects microtubules

Griseofulvin (CAS 126-07-8)

Griseofulvin | CAS 126-07-8 is rated 5.0 out of 5 by 1.
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Synonym: ; (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dioneAmudane
Application: An antifungal and antiproliferative agent that affects microtubules
CAS Number: 126-07-8
Purity: ≥99%
Molecular Weight: 352.77
Molecular Formula: C17H17CIO6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Griseofulvin, an antifungal agent, has been reported to inhibit proliferation of various types of cells. This compound has also been shown to strongly suppress the dynamic instability of individual microtubules via reduction of the rate and extent of the growing and shortening phases. The effects that griseofulvin has on microtubules can cause mitotic arrest and abnormalities, such as multipolar spindles, misaligned chromosomes, and fragmented nuclei.


References

1. Jin, H., et al. 2008. Hepatol. Res. 38: 909-918. PMID: 18624717
2. Martinez, Mdel. C., et al. 2009. Cell. Mol. Biol. 55: 127-139. PMID: 19656461
3. Rathinasamy, K., et al. 2010. BMC Cancer. 10: 213. PMID: 20482847

Physical State :
Solid
Derived From :
Penicillium sp.
Solubility :
Soluble in ethanol, DMF (50 mg/ml), methanol, chloroform, and DMSO.
Storage :
Store at -20° C
Melting Point :
218-220° C
Boiling Point :
~570.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +354°, c = 1 in DMF
IC50 :
Trichophyton mentagrophytes: IC50 = 58 nM; Trichophyton rubrum: IC50 = 380 nM; V79: IC50 = 8 µM (Cricetulus griseus); CEM: IC50 = 10 µM (human); MDA-MB-231: IC50 = 18 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WG9800000
PubChem CID :
441140
Merck Index :
14: 4549
MDL Number :
MFCD00082343
EC Number :
204-767-4
Beilstein Registry :
95226
SMILES :
CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC

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Certificate of Analysis

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Griseofulvin  Product Citations

See how others have used Griseofulvin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 12049842  Tseng, CJ. et al. 2002. Toxicology. 175: 123-142.

PMID: # 12049842  Tseng, CJ. et al. 2002. Toxicology. 175: 123-142.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Tseng Tseng, CJ. et al. (PubMed 12049842) used Griseofulvin, an antifungal agent that has shown to cause mitotic arrest by affecting microtubules, as a positive control against other potential microtubule damaging agents. -SCBT Publication Review
Date published: 2015-02-18
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