Griseofulvin, an antifungal agent, has been reported to inhibit proliferation of various types of cells. This compound has also been shown to strongly suppress the dynamic instability of individual microtubules via reduction of the rate and extent of the growing and shortening phases. The effects that griseofulvin has on microtubules can cause mitotic arrest and abnormalities, such as multipolar spindles, misaligned chromosomes, and fragmented nuclei.
1. Jin, H., et al. 2008. Hepatol. Res. 38: 909-918. PMID: 18624717 2. Martinez, Mdel. C., et al. 2009. Cell. Mol. Biol. 55: 127-139. PMID: 19656461 3. Rathinasamy, K., et al. 2010. BMC Cancer. 10: 213. PMID: 20482847
Soluble in ethanol, DMF (50 mg/ml), methanol, chloroform, and DMSO.
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TsengTseng, CJ. et al. (PubMed 12049842) used Griseofulvin, an antifungal agent that has shown to cause mitotic arrest by affecting microtubules, as a positive control against other potential microtubule damaging agents. -SCBT Publication Review
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