Granzyme B inhibitor is a weak inhibitor of murine and human Granzyme B. It also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, which is a rat lymphocyte granule protease homologous to Granzyme B (ID50 = 300 nM).
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Asked by: liya
Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Thank you for your question. SC-3087 is an irreversible, cell-permeable inhibitor of granzyme B. Above are some references that may help.
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