Granzyme B InhibitorA weak inhibitor of Granzyme B

Granzyme B Inhibitor

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Synonym: Z-Ala-Ala-Asp-CH2Cl
Application: A weak inhibitor of Granzyme B
Purity: ≥95%
Molecular Weight: 441.9
Molecular Formula: C19H24ClN3O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Granzyme B inhibitor is a weak inhibitor of murine and human Granzyme B. It also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, which is a rat lymphocyte granule protease homologous to Granzyme B (ID50 = 300 nM).

Physical State :
Solid
Sequence :
Z-Ala-Ala-Asp(OMe)-CMK
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760474
SMILES :
CC(C(=O)NC(CC(=O)CCl)C(=O)O)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1

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Certificate of Analysis

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这种抑制剂是颗粒酶B的可逆抑制剂吗,是与颗粒酶的底物竞争性抑制还是直接抑制颗粒酶的活性

Asked by: liya
感谢您的提问。SC-3087为颗粒酶B的不可逆、细胞渗透型抑制剂。更多信息请参考以下文献: Gong, B., et al. 1999. Cell Growth Different. 10, 491. Shi, L., et al. 1992. J. Exp. Med. 176, 1521. Odake, S., et al. 1991. Biochemistry 30, 2217. Thank you for your question. SC-3087 is an irreversible, cell-permeable inhibitor of granzyme B. Above are some references that may help.
Answered by: Technical Support 12
Date published: 2016-10-19
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