GP-AMC, Fluorogenic Substrate Used to study the activity of CD26, DPP7, DPP8, FAP, and PREP

GP-AMC, Fluorogenic Substrate (CAS 115035-46-6)

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Synonym: Gly-Pro-7-amido-4-methylcoumarin hydrobromide; Gly-Pro-AMC
Application: Used to study the activity of CD26, DPP7, DPP8, FAP, and PREP
CAS Number: 115035-46-6
Purity: >97%
Molecular Weight: 410.3
Molecular Formula: C17H19N3O4 HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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GP-AMC, Fluorogenic Substrate is a substrate with an excitation at 380 nm and emission at 460 nm. The substrate has been used to study the activity of CD26 (DPIV and DPPIV), DPP7 (DPPII/VII) , DPRP1 (DPP8), DPRP2 (DPP9), FAP (fibroblast activation protein), and POP/PREP. The compound has been used in a peptide assay where the release of AMC was monitored as well as in in vitro inhibtior screening.


References

1. Saric, T., et al. 2001. J. Biol. Chem. 276: 36474-36481. PMID: 11479311
2. Barinka, C., et al. 2002. J. Neurochem. 80: 477-487. PMID: 11905994
3. Leiting, B., et al. 2003. Biochem. J. 371: 525-532. PMID: 12529175
4. Bär, J., et al. 2003. Biol. Chem. 384: 1553-1563. PMID: 14719797
5. Villhauer, E.B., et al. 2003. J. Med. Chem. 46: 2774-2789. PMID: 12801240
6. Ashton, W.T., et al. 2004. Bioorg. Med. Chem. Lett. 14: 859-863. PMID: 15012982
7. Venäläinen, J.I., et al. 2006. Biochem. Pharmacol. 71: 683-692. PMID: 16405869

Physical State :
Solid
Sequence :
H-Gly-Pro-7-amino-4-methylcoumarin
Solubility :
Soluble in water (at least 120 mM).
Storage :
Store at -20° C
Boiling Point :
653.5° C
Fluoresence :
λex 380 nm, λem 460 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219396
MDL Number :
MFCD00152092
SMILES :
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C3CCCN3C(=O)CN.Br

Download SDS (MSDS)

Certificate of Analysis

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