Glycyrrhizin Acid Ammonium Salt A potent anti-viral agent

Glycyrrhizin Acid Ammonium Salt (CAS 53956-04-0)

Glycyrrhizin Acid Ammonium Salt | CAS 53956-04-0 is rated 5.0 out of 5 by 1.
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Synonym: Monoammonium glycyrrhizinate
Application: A potent anti-viral agent
CAS Number: 53956-04-0
Purity: ≥97%
Molecular Weight: 839.97
Molecular Formula: C42H62O16•NH3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Glycyrrhizin Ammonium salt is a constituent of the licorice root that has vital anti-viral activities that have been shown to inhibit the expression of 11β-HSD2 (11β-hydroxysteroid dehydrogenase type 2) via an indirect mechanism. Studies suggest that nitric oxide production is amplified in the macrophage cell line RAW264-7 and IFN-γ activated-macrophages. Furthermore, Glycyrrhizin stimulates the tumor cell killing effects of IFN -γ activated-macrophages. In addition the expression of COX-2 (cyclooxygenase-2) and NOS2 (inducible nitric oxide synthase, INOS) are inhibited by Glycyrrhizin. This product has been shown to suppress the growth and acid producing effects of S. mutans in vitro.


References

1. Kondo, Y., et al. 1994. Biol. Pharm. Bull. 17: 759-761. PMID: 7920451
2. Tanahashi, T., et al. 2002. J. Steroid Biochem. Mol. Biol. 80: 441-447. PMID: 11983491
3. Cinatl, J., et al. 2003. Lancet. 361: 2045-2046. PMID: 12814717
4. Thirugnanam, S., et al. 2008. Oncol. Rep. 20: 1387-1392. PMID: 19020719
5. Tanaka, N., et al. 2009. J. Gastroenterol. 44: 577-582. PMID: 19352587

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in 1 M NH4OH (50 mg/ml), and Acetic Acid.
Storage :
Store at 4° C
Melting Point :
209-211° C
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D 51.5°, c = 1.5 in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
LZ6500000
PubChem CID :
62074
Merck Index :
14: 4505
MDL Number :
MFCD00167400
EC Number :
258-887-7
Beilstein Registry :
3897076
SMILES :
C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.N

Download SDS (MSDS)

Certificate of Analysis

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Glycyrrhizin Acid Ammonium Salt  Product Citations

See how others have used Glycyrrhizin Acid Ammonium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28670282  Fei, L. et al. 2017. Front Pharmacol. 8: 389.

PMID: # 2038692  Boutmy, E. et al. 1991. Soins. 55-56.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Zhao Zhao, H. et al. (PubMed 26385569) reported that Glycyrrhizic acid prevents sepsis-induced acute lung injury and mortality in rats. -SCBT Publication Review
Date published: 2015-01-15
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