Glycylglycine, Free BaseA dipeptide used as a buffering reagent

Glycylglycine, Free Base (CAS 556-50-3)

Glycylglycine, Free Base | CAS 556-50-3 is rated 5.0 out of 5 by 1.
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Synonym: 2-[(2-aminoacetyl)amino]acetic acid
Application: A dipeptide used as a buffering reagent
CAS Number: 556-50-3
Purity: ≥99%
Molecular Weight: 132.12
Molecular Formula: C4H8N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Glycylglycine (Gly-Gly) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Also useful as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption.


References

1. Cowell, J.L. 1974. J. Bacteriol. 120: 139-146. PMID: 4278690
2. Cook, G.C. 1976. Gut. 17: 252-257. PMID: 773786
3. Fujiwara, T., et al. 2005. J. Bacteriol. 187: 480-487. PMID: 15629919
4. Feyer, V., et al. 2009. J Phys Chem A. 113: 10726-10733. PMID: 19757775
5. Kurhe, D.N., et al. 2009. J Phys Chem B. 113: 16612-16621. PMID: 19924870
6. Iida, T., et al. 2009. J. Dermatol. 36: 120-123. PMID: 19284462

Physical State :
Solid
Solubility :
Soluble in water (132 g/l) at 20° C, and ethanol (slightly solube).
pH :
7.5-8.9
Storage :
Store at room temperature
Melting Point :
255-260° C
Boiling Point :
~453.24° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
pK Values :
pKa: 8.2 (25° C)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11163
Merck Index :
14:4503
MDL Number :
MFCD00008130
EC Number :
209-127-8
Beilstein Registry :
1765223
SMILES :
C(C(=O)NCC(=O)O)N

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Certificate of Analysis

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Glycylglycine, Free Base  Product Citations

See how others have used Glycylglycine, Free Base. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 19757775  Feyer, V. et al. 2009. J Phys Chem A. 113: 10726-10733.

PMID: # 19924870  Kurhe, DN. et al. 2009. J Phys Chem B. 113: 16612-16621.

PMID: # 15629919  Fujiwara, T. et al. 2005. J. Bacteriol. 187: 480-487.

PMID: # 773786  Cook, GC. et al. 1976. Gut. 17: 252-257.

PMID: # 4278690  Cowell, JL. et al. 1974. J. Bacteriol. 120: 139-146.

Citations 1 to 5 of 5 total

We ordered Glycylglycine, free base, lot:I1015. For our purpose the impurity of glycine in glycylglycine shall not exceed 0,1%. This impurity is not mentioned in the COA. The purity of glycylglicine is 99.9%, shall the glycine impurity be <0,1%?

Asked by: Anja Spaans
Thank you for your question. The purity was determined by titration. However, based on the age of the lot we would recommend that you retest the product before use. Please contact our Technical Service Department for additional support. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-12-04
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Rated 5 out of 5 by from Various publications cite Glycylglycine (Free Various publications cite Glycylglycine (Free Base) for its use in peptide transport and absorption assays. It is also a practical buffer above a pH of 8.0. -SCBT Publication Review
Date published: 2015-05-22
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