Gly-Phe beta-naphthylamideA substrate for cathepsin C and inhibitor of caspase-8

Gly-Phe β-naphthylamide (CAS 21438-66-4)

Gly-Phe β-naphthylamide, CAS 21438-66-4 is rated 5.0 out of 5 by 2.
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Synonym: Glycylphenylalanine2-naphthylamide
Application: A substrate for cathepsin C and inhibitor of caspase-8
CAS Number: 21438-66-4
Purity: ≥95%
Molecular Weight: 347.41
Molecular Formula: C21H21N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gly-Phe-β-naphthylamide is a cathepsin C substrate. The compound is described to accumulate inside lysosomes leading to their destruction. Studies report that Gly-Phe-β-naphthylamide significantly inhibits the activation of caspase-8, and has also been used to study recombinant cathepsin C.


References

1. Baumgartner, H.K., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G296-G307. PMID: 17431216
2. Qiu, G.F., et al. 2009. J. Biomed. Biotechnol. 2009. 746289. PMID: 19707514

Appearance :
Crystalline
Physical State :
Solid
Solubility :
100mg in 200µl DMSO
Storage :
Store at -20° C
Melting Point :
155-158° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
152423
MDL Number :
MFCD00021597
SMILES :
C1=CC=C(C=C1)C[C@@H](C(=O)NC2=CC3=CC=CC=C3C=C2)NC(=O)CN

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Gly-Phe beta-naphthylamide  Product Citations

See how others have used Gly-Phe beta-naphthylamide. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 30820356  Li, C.|Huang, L.|Sun, W.|Chen, Y.|He, ML.|Yue, J.|Ballard, H.| et al. 2019. Signal Transduct Target Ther. 4: 4.

PMID: # 29622626  Skowyra, ML. et al. 2018. Science. 360:

PMID: # 28742019  Chakraborty, K.|Leung, K.|Krishnan, Y.| et al. 2017. Elife. 6:

PMID: # 28970837  Tseng, HHL. et al. 2017. Front Immunol. 8: 1161.

PMID: # 28486130  Sahoo, N.|Gu, M.|Zhang, X.|Raval, N.|Yang, J.|Bekier, M.|Calvo, R.|Patnaik, S.|Wang, W.|King, G.|Samie, M.|Gao, Q.|Sahoo, S.|Sundaresan, S.|Keeley, TM.|Wang, Y.|Marugan, J.|Ferrer, M.|Samuelson, LC.|Merchant, JL.|Xu, H.| et al. 2017. Dev. Cell. 41: 262-273.e6.

PMID: # 29270011  Fontana, JM.|Yin, H.|Chen, Y.|Florez, R.|Brismar, H.|Fu, Y.| et al. 2017. Int J Nanomedicine. 12: 8615-8629.

PMID: # 27477609  Zhong, XZ. et al. 2016. J. Physiol. (Lond.). 594: 4253-66.

PMID: # 25665438  Kilpatrick, BS. et al. 2015. Methods Cell Biol. 126: 1-19.

PMID: # 26101220  Cao, Q. et al. 2015. J. Cell Biol. 209: 879-94.

PMID: # 25394380  Chen, WT. et al. 2015. Mol. Neurobiol. 52: 1835-49.

Citations 1 to 10 of 14 total
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Rated 5 out of 5 by from it works well. We have use it for several years, and it always works well for our experiment. We usually do calcium image and it works well to release lysosomal calcium.
Date published: 2017-04-17
Rated 5 out of 5 by from It worked well in our experiment It worked well in our experiment.
Date published: 2015-09-03
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