Glucocorticoid Receptor Modulator, CpdA Glucocorticoid Receptor Modulator, CpdA is a non-steroidal, GR-activating ligand with higher binding affinity than dexamethasone (sc-29059).

Glucocorticoid Receptor Modulator, CpdA  (CAS 14593-25-0)

Glucocorticoid Receptor Modulator, CpdA is rated 5.0 out of 5 by 1.
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| See 1 Citations
Synonym: 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
Application: A cell-permeable aziridine precursor
CAS Number: 14593-25-0
Purity: ≥97%
Molecular Weight: 264.15
Molecular Formula: C11H14ClNO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Glucocorticoid Receptor Modulator, CpdA sc-221677 25 mg $130.00

Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), and water (1 mg/ml).
Storage :
Store at -80° C
Melting Point :
184-191° C
Refractive Index :
n20D ~1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9838147
MDL Number :
MFCD16883076
SMILES :
CC(=O)OC1=CC=C(C=C1)C(CNC)Cl.Cl

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PMID: # 25389358
Malaise, O. et al. 2015. Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. Rheumatology (Oxford). 54: 1087-92.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Saksida Saksida, T. et al. (PubMed 25158597) reported that CpdA (Compound A), a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice. -SCBT Publication Review
Date published: 2015-02-09
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