|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
|Glucocorticoid Receptor Modulator, CpdA||sc-221677||25 mg||$130.00||
Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.
See how others have used Glucocorticoid Receptor Modulator, CpdA. Click on the entry to view the PubMed entry .
PMID: # 25389358
Malaise, O. et al. 2015. Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts. Rheumatology (Oxford). 54: 1087-92.
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