Ginkgolide B A potent PAF-R antagonist

Ginkgolide B (CAS 15291-77-7)

Ginkgolide B | CAS 15291-77-7 is rated 4.0 out of 5 by 1.
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Synonym: Ginkolide B; BN 52021
Application: A potent PAF-R antagonist
CAS Number: 15291-77-7
Purity: ≥90%
Molecular Weight: 424.40
Molecular Formula: C20H24O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ginkgolide B (BN 52021), originally extracted from Ginkgo biloba leaves, is the most potent member of the ginkgolide family of PAF-R (platelet-activating factor receptor) antagonists. PAF is an important mediator of many biological processes including cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation. Mechanistic studies suggest that Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally, this compound has been reported to inhibit neutrophil degranulation in vitro.


References

1. Nunez, D., et al. 1986. Eur. J. Pharmacol. 123: 197-205. PMID: 3086108
2. Desquand, S., et al. 1986. Eur. J. Pharmacol. 127: 83-95. PMID: 3019727
3. Tamura, N., et al. 1987. Biochem. Biophys. Res. Commun. 142: 638-644. PMID: 3030295
4. Vercellotti, G.M., et al. 1988. Blood. 71: 1100-1107. PMID: 2451547
5. Korth, R., et al. 1988. Eur. J. Pharmacol. 152: 101-110. PMID: 2850196
6. van Beek, T.A., et al. 2005. Bioorg. Med. Chem. 13: 5001-5012. PMID: 15993092

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (25 mM), acetone, ethyl acetate, dioxane, methanol, and water (partly miscible).
Storage :
Store at -20° C
Melting Point :
295-296° C
Boiling Point :
~762.4° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.65
IC50 :
PAF-induced PMNL chemotaxis: IC50 = 490 nM
Ki Data :
PAF receptor: Ki= 1.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
65243
Merck Index :
14: 4426
MDL Number :
MFCD05662347
SMILES :
CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O

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Certificate of Analysis

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Ginkgolide B  Product Citations

See how others have used Ginkgolide B. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26778968  Hammond, JW. et al. 2015. Front Cell Neurosci. 9: 505.

PMID: # 24044991  Lin, W. et al. 2013. Analytical biochemistry. 443: 252-60.

Citations 1 to 2 of 2 total
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Date published: 2015-04-20
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