GeranylgeraniolAn intermediate in the mevalonate pathway

Geranylgeraniol (CAS 24034-73-9)

Geranylgeraniol | CAS 24034-73-9 is rated 5.0 out of 5 by 1.
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Synonym: Tetraprenol; all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol
Application: An intermediate in the mevalonate pathway
CAS Number: 24034-73-9
Purity: ≥95%
Molecular Weight: 290.48
Molecular Formula: C20H34O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.


References

1. Aiuchi, T., et al. 1998. J. Biochem. 124: 300-303. PMID: 9685718
2. Fisher, J.E., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138. PMID: 9874784
3. Montero, M.T., et al. 2004. J. Immunol. 173: 4936-4944. PMID: 15470035
4. Campia, I., et al. 2009. Br. J. Pharmacol. 158: 1777-1786. PMID: 19888963

Appearance :
Neat oil
Physical State :
Liquid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), chloroform, dichloromethane, ethyl acetate, hexane, ether, and acetone.
Storage :
Store at -80° C
Refractive Index :
n20D 1.49
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5281365
MDL Number :
MFCD00129083
Beilstein Registry :
1913779
SMILES :
CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C

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Certificate of Analysis

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Geranylgeraniol  Product Citations

See how others have used Geranylgeraniol. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 29167270  Schumacher, MM. et al. 2018. J. Biol. Chem. 293: 312-323.

PMID: # 28351924  McLean, KJ. et al. 2017. MBio. 8:

PMID: # 27121042  Schumacher, MM. et al. 2016. J. Lipid Res. 57: 1286-99.

PMID: # 24573296  Mathews, ES. et al. 2014. J. Neurosci. 34: 3402-12.

PMID: # 24860107  Morris, LL. et al. 2014. J. Biol. Chem. 289: 19053-66.

PMID: # 15247248  Sever, N. et al. 2004. J Biol Chem. 279: 43136-43147.

PMID: # 9874784  Fisher, JE. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138.

PMID: # 9157972  Miquel, K. et al. 1997. Cancer Res. 57: 1846-1850.

PMID: # 8617711  Otto, JC. et al. 1996. J. Biol. Chem. 271: 4569-4572.

PMID: # 7775375  Ohizumi, H. et al. 1995. J. Biochem. 117: 11-13.

Citations 1 to 10 of 10 total

solubility character of Genanyl geraniol

Asked by: senjesh
Thank you for your question. This biochemical is soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), chloroform, dichloromethane, ethyl acetate, hexane, ether, and acetone.If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2018-01-18
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Rated 5 out of 5 by from Sever Sever, et. al. (PubMed ID 15247248) found that when cells were treated with both SR-12813 and geranylgeraniol, the reductase degradation was sped up (determined by seeing a dramatic decrease in the reductase band by Western Blot analysis). -SCBT Publication Review
Date published: 2015-03-07
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