Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.
1. Aiuchi, T., et al. 1998. J. Biochem. 124: 300-303. PMID: 9685718
2. Fisher, J.E., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138. PMID: 9874784
3. Montero, M.T., et al. 2004. J. Immunol. 173: 4936-4944. PMID: 15470035
4. Campia, I., et al. 2009. Br. J. Pharmacol. 158: 1777-1786. PMID: 19888963
See how others have used Geranylgeraniol. Click on the entry to view the PubMed entry .
PMID: # 24573296
Mathews, ES. et al. 2014. Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. J. Neurosci.. 34: 3402-12.
PMID: # 15247248
Sever, N. et al. 2004 . Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J Biol Chem.. 279: 43136-43147.
PMID: # 9874784
Fisher, JE. et al. 1999. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc. Natl. Acad. Sci. U.S.A.. 96: 133-138.
PMID: # 9157972
Miquel, K. et al. 1997. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Cancer Res.. 57: 1846-1850.
PMID: # 8617711
Otto, JC. et al. 1996. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. J. Biol. Chem.. 271: 4569-4572.
PMID: # 7775375
Ohizumi, H. et al. 1995. Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J. Biochem.. 117: 11-13.
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