Geranylgeraniol Geranylgeraniol, is an intermediate in the mevalonate pathway, that has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro.

Geranylgeraniol  (CAS 24034-73-9)

Geranylgeraniol is rated 5.0 out of 5 by 1.
  • 2016-09-27T11:11CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200858, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
| See 6 Citations
Synonym: Tetraprenol; all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol
Application: An intermediate in the mevalonate pathway
CAS Number: 24034-73-9
Purity: ≥95%
Molecular Weight: 290.48
Molecular Formula: C20H34O
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Geranylgeraniol sc-200858 20 mg $79.00
Geranylgeraniol sc-200858A 100 mg $312.00

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.


References

1. Aiuchi, T., et al. 1998. J. Biochem. 124: 300-303. PMID: 9685718
2. Fisher, J.E., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138. PMID: 9874784
3. Montero, M.T., et al. 2004. J. Immunol. 173: 4936-4944. PMID: 15470035
4. Campia, I., et al. 2009. Br. J. Pharmacol. 158: 1777-1786. PMID: 19888963

Appearance :
Neat oil
Physical State :
Liquid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), chloroform, dichloromethane, ethyl acetate, hexane, ether, and acetone.
Storage :
Store at -80° C
Melting Point :
40.20° C (Predicted)
Boiling Point :
~397.1° C at 760 mmHg (Predicted)
Density :
0.88 g/mL
Refractive Index :
n20D 1.49
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5281365
MDL Number :
MFCD00129083
Beilstein Registry :
1913779
SMILES :
CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

Geranylgeraniol Product Citations

See how others have used Geranylgeraniol. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 24573296
Mathews, ES. et al. 2014. Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. J. Neurosci.. 34: 3402-12.

PMID: # 15247248
Sever, N. et al. 2004 . Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J Biol Chem.. 279: 43136-43147.

PMID: # 9874784
Fisher, JE. et al. 1999. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc. Natl. Acad. Sci. U.S.A.. 96: 133-138.

PMID: # 9157972
Miquel, K. et al. 1997. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Cancer Res.. 57: 1846-1850.

PMID: # 8617711
Otto, JC. et al. 1996. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. J. Biol. Chem.. 271: 4569-4572.

PMID: # 7775375
Ohizumi, H. et al. 1995. Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J. Biochem.. 117: 11-13.

Citations 1 to 6 of 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 85ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Sever Sever, et. al. (PubMed ID 15247248) found that when cells were treated with both SR-12813 and geranylgeraniol, the reductase degradation was sped up (determined by seeing a dramatic decrease in the reductase band by Western Blot analysis). -SCBT Publication Review
Date published: 2015-03-07
  • 2016-09-27T11:11CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200858, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2016 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.