Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.
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See how others have used Geranylgeraniol. Click on the entry to view the PubMed entry .
PMID: # 24573296
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Miquel, K. et al. 1997. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Cancer Res.. 57: 1846-1850.
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Otto, JC. et al. 1996. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. J. Biol. Chem.. 271: 4569-4572.
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Ohizumi, H. et al. 1995. Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J. Biochem.. 117: 11-13.
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