Geneticin (G418) Sulfate An aminoglycoside antibiotic

Geneticin (G418) Sulfate  (CAS 108321-42-2)

Geneticin (G418) Sulfate | CAS 108321-42-2 is rated 4.7 out of 5 by 3.
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| See 21 Citations
Synonym: Antibiotic G418
Application: An aminoglycoside antibiotic
CAS Number: 108321-42-2
Molecular Weight: 692.71
Molecular Formula: C20H40N4O102H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Geneticin (G418) Sulfate sc-29065 1 g $45.00
Geneticin (G418) Sulfate sc-29065A 5 g $159.00
Geneticin (G418) Sulfate sc-29065B 25 g $406.00

Geneticin (G418) Sulfate is an aminoglycoside antibiotic that has originally been derived from Micromonospora rhodoranga NRRL 5326. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that geneticin sulfate inhibits the incorporation of amino acids into protein and can destroy fibroblasts. Mechanistic studies suggest that this agent affects the 80S ribosome and inhibits the elongation cycle. Further studies report that geneticin sulfate is highly active against amoebae, protozoa, tapeworm, and pinworm exposed murine cells.


References

1. Wagman, G.H., et al. 1974. Antimicrob. Agents Chemother. 6: 144-149. PMID: 15828184
2. Bar-Nun, S., et al. 1983. Biochim. Biophys. Acta. 741: 123-127. PMID: 6193810
3. Halaban, R. and Alfano, F.D. 1984. In Vitro. 20: 447-450. PMID: 6724622
4. Yang, C., et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 15394-15399. PMID: 17881586

Usage :
• Potency: ≥700 μg/mg
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml) and aqueous buffers.
Storage :
Store at 4° C
Boiling Point :
1012.1° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760463
MDL Number :
MFCD00058314
SMILES :
C[C@H]([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Geneticin (G418) Sulfate Product Citations

See how others have used Geneticin (G418) Sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 21 total

PMID: # 26648003
Ying, Z. et al. 2015. Effect of Hath1 on the proliferation and apoptosis of cutaneous squamous cell carcinoma in vitro. Mol Med Rep. 12: 7845-50.

PMID: # 25757558
Ghose, J. et al. 2015. Transcriptional regulation of microRNA-100, -146a, and -150 genes by p53 and NFκB p65/RelA in mouse striatal STHdh(Q7)/ Hdh(Q7) cells and human cervical carcinoma HeLa cells. RNA Biol. 12: 457-77.

PMID: # 25286822
Tomellini, E. et al. 2015. Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment. Stem Cells. 33: 342-53.

PMID: # 25759266
Ismail, OZ. et al. 2015. Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury. Am. J. Pathol.. 185: 1207-15.

PMID: # 26697979
Ismail, O. et al. 2015. G protein, 12 (Gα12) is a negative regulator of kidney injury molecule-1-mediated efferocytosis. Am. J. Physiol. Renal Physiol.. ajprenal.00169.2015.

PMID: # 25526449
Hlaváč, V. et al. 2014. The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Medicine (Baltimore). 93: e255.

PMID: # 25331979
Mateo, F. et al. 2014. SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations. Molecular cancer. 13: 237.

PMID: # 25139909
Ryan, OW. et al. 2014. Selection of chromosomal DNA libraries using a multiplex CRISPR system. Elife. 3:

PMID: # 24606125
Eigler, T. et al. 2014. Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol. Endocrinol.. 28: 554-64.

PMID: # 23720720
Liu, Z. et al. 2013. Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors. J. Virol.. 87: 8545-58.

Citations 1 to 10 of 21 total

What is the potency of this chemical?

Asked by: 13punMA
Thank you for your question. Geneticin (G418) Sulfate Potency has been determined for previous lots to be ≥700 μg/mg. You may request a lot-specific CoA on our website for current information.
Answered by: Technical Support
Date published: 2017-03-09

Is this cell culture grade? Have the endotoxin levels been tested? And is sterility guaranteed?

Asked by: 13punMA
This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood. The endotoxin levels are not normally tested but a custom assessment can be done for an additional fee. Sterility cannot be guaranteed.
Answered by: Tech Service 11
Date published: 2017-02-24

After dissolving Geneticin (G418) Sulfate (CAS 108321-42-2) in water, where should I store it? Can it be frozen long term?

Asked by: two2igm05
We recommend that solutions be used the same day they were made. For short term storage (less than 6 months), the solution may be aliquotted it into useable amounts and stored frozen (-20ºC to -80ºC). Multiple freeze/thaw cycles should be avoided.
Answered by: Tech Service 11
Date published: 2017-02-24
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Rated 4 out of 5 by from G418 Great product.. it worked beautifully in U2OS cells
Date published: 2017-02-02
Rated 5 out of 5 by from Used in cell selection Used in cell selection, worked great.
Date published: 2015-04-05
Rated 5 out of 5 by from By treating HeLa cells with 8 g/ml of Geneticin By treating HeLa cells with 8 g/ml of Geneticin (G418) Sulfate for 48 hours, one can observe great cell death by staining with trypan blue. This compound is found to inhibit the incorporation of amino acids into proteins. -SCBT QC
Date published: 2015-02-20
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