Gemcitabine Hydrochloride (CAS 122111-03-9)

Gemcitabine Hydrochloride | CAS 122111-03-9 is rated 5.0 out of 5 by 1.

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Synonym: 2'-Deoxy-2',2'-difluorocytidine HCL; LY-188011 . HCl

Application: A deoxycytidine analog that inhibits ribonucleotide reductase & induces apoptosis

CAS Number: 122111-03-9

Purity: ≥99%

Molecular Weight: 299.66

Molecular Formula: C₉H₁₁F₂N₃O₄•HCl

* Refer to Certificate of Analysis for lot specific data (including water content).

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Gemcitabine Hydrochloride is a deoxycytidine analog with cytotoxic effects. Gemcitabine Hydrochloride inhibits DNA synthesis and induces apoptosis through inhibition of ribonucleotide reductase (R1 and R2).

References

1. Heinemann, V., et al. 1992. Cancer Res. 52: 533-539. PMID: 1732039
2. Plunkett, W., et al. 1995. Semin. Oncol. 22: 3-10.PMID: 7481842
3. Hui, Y.F., et al. 1997. Am. J. Health Syst. Pharm. 54: 162 -170. PMID: 9117804
4. Mini, E., et al. 2006. Ann. Oncol. 17: 7-12. PMID: 16807468

Physical State :

Solid

Solubility :

Soluble in water (100 mM), methanol (slightly), DMSO (50 mM), and acetone. Insoluble in ethanol.

Storage :

Store at 4° C

Melting Point :

292° C (lit.)

Boiling Point :

482.7° C at 760 mmHg (Predicted)

Refractive Index :

n²⁰_D 1.65 (Predicted)

Optical Activity :

α20/D +46.5°±3.5°, c = 1 in deuterated water; α25/D +71.51°, c = 0.96 in methanol

IC50 :

NCI-H460: IC₅₀ = 2.13 nM (human); Growth of C2G prostate cancer cell line : IC₅₀ = 3.7 nM; TRAMP-C2H: IC₅₀ = 4.7 nM (mouse); TRAMP-C1A: IC₅₀ = 9 nM (mouse); Growth of C2D prostate cancer cell line : IC₅₀ = 11.9 nM

pK Values :

pK_a: pK₁: 5.27 in imine, pK₂: 11.24 in alcohol (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

HA3840000

PubChem CID :

60749

Merck Index :

14: 4386

MDL Number :

MFCD01735988

EC Number :

601-823-3

Beilstein Registry :

5386970

SMILES :

C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl

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Certificate of Analysis

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Gemcitabine Hydrochloride Product Citations

See how others have used Gemcitabine Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 27814544 Isidori, M. et al. 2016. Environ. Pollut. 219: 275-287.

PMID: # 26971211 Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.

PMID: # 26013168 Ono, H. et al. 2015. Mol. Cancer Res. 13: 1174-84.

PMID: # 25124055 Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.

PMID: # 24583265 Kondratska, K. et al. 2014. Biochim. Biophys. Acta. 1843: 2263-9.

PMID: # 24667756 Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24148406 2013. Talanta. 116: 290-9.

PMID: # 23357749 Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.

PMID: # 23055553 Zhu, J. et al. 2012. J. Virol. 86: 13689-96.

PMID: # 19157636 Hsu, IL. et al. 2009. Lung Cancer. 65: 371-376.

Citations 1 to 10 of 10 total

After solubilized in DMSO and stored in 4℃, Gemcitabine Hydrochloride (sc-204763) solution becomes solid. How stable is it if I thaw the solution and put it back to 4℃ to let it become solid and then thaw, which results in multiple cycles?

Asked by: BailuXie

Thank you for your question. It is recommended to store stock solutions at -20 or below and use within 1 month. We do not have any data on stability after multiple freeze-thaw cycles. It is recommended wherever possible solutions should be made and used on the same day.

Answered by: Tech Service

Date published: 2019-03-08

After solubilization in DMSO, at what temperature should the solution be stored?

Asked by: two2igm05

Thank you for your question. Gemcitabine Hydrochloride, sc-204763, can be stored for 6 months at -80℃ in solvent.

Answered by: TechService7

Date published: 2016-12-28

What is the solubility of this product in water?

Asked by: hawkeye11

It's clear water solution. Gemcitabine Hydrochloride, sc-204763, is solubility in water at around 19 mg/mL at room temperature.

Answered by: TechService7

Date published: 2016-12-20

Rated 5 out of 5 by MS from Takeuchi Takeuchi, H. et al. (PubMed 26323344) found that sequential treatment with gemcitabine and tamoxifen led to increased apoptosis in bladder cancer cell lines. -SCBT Publication Review

Date published: 2015-04-21

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Gemcitabine Hydrochloride (CAS 122111-03-9)

QUICK LINKS

References

Download SDS (MSDS)

Certificate of Analysis

Gemcitabine Hydrochloride Product Citations

After solubilized in DMSO and stored in 4℃, Gemcitabine Hydrochloride (sc-204763) solution becomes solid. How stable is it if I thaw the solution and put it back to 4℃ to let it become solid and then thaw, which results in multiple cycles?

After solubilization in DMSO, at what temperature should the solution be stored?

What is the solubility of this product in water?

Gemcitabine Hydrochloride (CAS 122111-03-9)

QUICK LINKS

References

Download SDS (MSDS)

Certificate of Analysis

Gemcitabine Hydrochloride Product Citations

After solubilized in DMSO and stored in 4℃, Gemcitabine Hydrochloride (sc-204763) solution becomes solid. How stable is it if I thaw the solution and put it back to 4℃ to let it become solid and then thaw, which results in multiple cycles?

After solubilization in DMSO, at what temperature should the solution be stored?

What is the solubility of this product in water?

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