Gedunin Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity.

Gedunin  (CAS 2753-30-2)

Gedunin is rated 5.0 out of 5 by 1.
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| See 1 Citations
Synonym: (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12­aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b­,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethylox­ireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Application: An Hsp90 inhibitor
CAS Number: 2753-30-2
Purity: >98%
Molecular Weight: 482.57
Molecular Formula: C28H34O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Gedunin sc-203967 10 mg $185.00

Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).


References

1. Uddin, Shaikh J., et al., 2007. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 21(8): 757-61. PMID: 17450509
2. Lee, Sung-Eun., et al., 2008. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 15(6-7): 533-5. PMID: 17913482
3. Brandt, Gary E L., et al., 2008. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of medicinal chemistry. 51(20): 6495-502. PMID: 18816111

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (10 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +60.8º, c = 1 in methanol
IC50 :
P. falciparum in parasite development : IC50 = 0.14 µM; P. falciparum in [3H]-hypoxanthine uptake assays : IC50 = 3.1 µM; SKBr3: IC50 = 3.22 µM; MCF-7: IC50 = 8.84 µM; CaCo-2 : IC50 = 16.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
LK9275200
PubChem CID :
5701985
SMILES :
CC(=O)O[C@@H]1CC2[C@](C=CC(=O)C2(C)C)(C3[C@@]1([C@]45[C@H](O4)C(=O)O[C@H]([C@@]5(CC3)C)C6=COC=C6)C)C

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Certificate of Analysis

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Citations 1 to 1 of 1 total

PMID: # 26284260
Edwards, MR. et al. 2015. High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication. ACS infectious diseases. 1: 380-387.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Borges PV; et al Borges PV; et al. (PubMed ID: 26330549) Determined that Gedunin blocks the formation of TLR4/MD-2/LPS complex and acts as a competitive inhibitor of LPS. -SCBT Publication Review
Date published: 2015-02-21
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