GED bicarbonateA peroxynitrite scavenger NOS inhibitor

GED bicarbonate (CAS 1072-13-5)

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Synonym: Guanidinoethyldisulfide • 2HCO3; 2-Guanidinoethyl disulfide
Application: A peroxynitrite scavenger NOS inhibitor
CAS Number: 1072-13-5
Molecular Weight: 360.41
Molecular Formula: C6H16N6S2.H4C2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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GED bicarbonate is a peroxynitrite scavenger. It acts as a potent inhibitor of mouse inducible nitric oxide synthase (iNOS; NOS II).


References

1. Southan, G J., et al., 1996. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. British journal of pharmacology. 117(4): 619-32. PMID: 8646406
2. Szabó, C., et al., 1996. Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform. British journal of pharmacology. 118(7): 1659-68. PMID: 8842429
3. Mabley, Jon G., et al., 2004. The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro. Pancreas. 28(2): E39-44. PMID: 15028959

Physical State :
Solid
Solubility :
Soluble in Water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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